Toward Increased Precision and Efficiency in Macromolecular Synthesis: New Strategies and Enabling Functions

Motivated by nature, polymer chemists have long sought methods and strategies for the synthesis of macromolecules with precise structures. Existing approaches typically require a trade-off between structural control and atom economy/scalability. Seeking more efficient strategies, and driven by specific functional targets, we have developed approaches that simultaneously offer enhanced precision and efficiency in a variety of contexts. This talk will highlight several of these efforts, which include iterative exponential growth plus sidechain functionalization (IEG+), brush-first ring-opening metathesis polymerization, N-heterocyclic carbene surface anchors, photo-redox catalyzed growth, and network disassembly spectrometry. The advantages of these approaches for achieving new or otherwise difficult-to-access macromolecular functions will be discussed.

Division(s): Chemical Biology, Organic

Speaker: Jeremiah Johnson

Speaker Institution: MIT

Event Date: 02-19-2018

Event Time: 4:00 PM

Event Location: Chemistry A101

Mixer Time: 3:45 PM

Mixer Location: Chemistry B101E

Host: E. Chen