How does the motion of small and simple molecules vary between free and restricted environments?

Using a range of sophisticated spectroscopic approaches, we will examine how these motions can be correlated with molecular location over a range of time- and length-scales. 

These studies will also show how restricted environments influence chemical reactions by correlating small molecule motions and fluctuations to their overall chemistry, including the physical behavior and folding of biological macromolecules. 

Studies will also reveal whether restriction of molecular motion of otherwise highly mobile molecules influence processes on biological surfaces where reorganization of membrane components may initiate cell signaling.