Formation of in chemical reactions products depends on reactant motions and interactions. Because the motion of molecules varies with their location, reactions can also be influenced when reactants' motion changes within a restricted environment. To gauge how molecular motion and restriction impacts chemical reactions, we are studying representative systems for three classes of reactions including electron transfer, proton transfer and condensation reactions. We will use vanadium compounds to examine these reaction classes because vanadium compounds have proven to be excellent probes of confined environments and we have considerable experience with their chemistry. Our goal will be to characterize how molecular motion in confined media such as reverse micelles affects reactions which are known to be sensitive to molecular motion.  We expect to be carrying out reactions between reagents in one compartment, reactions between a reagent in the water phase and a reagent at the lipid-water interface and reactions between reagents in different reverse micelles. These reactions combined with studies described in Project 1 will allow us to determine the impact of confinement on these reactions.