Three longstanding and critical challenges in the field of chemical biology are:
(1) The development and application of high-throughput methods to identify small molecule - RNA interactions, which result in the sequence-selective regulation of an RNA's cellular function;
(2) The design and synthesis of molecules that selectively bind a targeted protein surface, and disrupt a targeted protein-protein interaction; and,
(3) The development and application of high-throughput methods to identify reagents capable of targeting the delivery of therapeutics and imaging reagents to diseased cells and tissue.
Researchers in The McNaughton Group address these challenges using methods in organic synthesis, combinatorial chemistry, molecular biology, and cell biology, in the context of high-throughput screening and evolution-based selections. |