Education and Employment
2006- A. I. Meyers Professor of Chemistry, Colorado State University
1998-2006 Professor of Chemistry, Yale University
1997-1998 Associate Professor of Chemistry (non tenured), Yale University
1993-1997 Assistant Professor of Chemistry, Yale University
1991-1993 American Cancer Society Postdoctoral Fellow, Harvard University
1985-1991 Ph.D., Organic Chemistry, University of Pennsylvania, Philadelphia, PA.
1980-1985 B.A., Chemistry, University of Colorado, Boulder, CO.
Honors and Awards
Katritzky Award in Heterocyclic Chemistry (ISHC) 2009
3éme Cycle Lectureship, University of Basel 2009
Distinguished Behringer Simon Lecturer, ETH Zurich 2009
Amgen Faculty Award 2005, 2006, 2007, 2008, 2009
Japanese Society for the Promotion of Science Fellow 2008
American Chemical Society Arthur C. Cope Scholar Award, 2004
Yamanouchi USA Faculty Award 1998, 1999, 2000, 2001, 2002, 2003
Merck Faculty Award 2000, 2001, 2002
Kitasato Microbial Chemistry Medal 2001
Bristol-Myers Squibb Foundation Research Award 1998-2001
Pfizer Research Award 1997-2001
Zeneca Excellence in Chemistry Award 1998
Dreyfus Teacher Scholar Award 1998
Novartis Chemistry Lectureship 1997-1998
Alfred P. Sloan Foundation Fellow 1997
Parke-Davis Distinguished Michigan Lecturer 1997
Bristol-Myers Squibb Research Award 1997
Glaxo-Wellcome Young Chemistry Scholar Award 1996-1998
Eli Lilly Young Faculty Award 1996-1997
Invited Visiting Professor, University of Auckland New Zealand 1997
Invited Guest Editor, Tetrahedron Symposium in Print on Synthetic Methods V 1997
NSF CAREER award 1996-2000
Yale University, Junior Faculty Fellowship, 1996-1997
American Cancer Society, Junior Faculty Award 1994
Camille and Henry Dreyfus New Faculty Award 1993
American Cancer Society Postdoctoral Fellowship 1991-1993
National Institutes of Health Postdoctoral Fellowship 1991-1993 (declined)
University of Pennsylvania Dean's Dissertation Fellowship 1989-1990
Distinguished Organic Chemistry Teaching Award 1986
B. A. in chemistry, Summa Cum Laude in Chemistry, 1985
Professional Service
Elected Member at Large, ACS Division of Organic Chemistry Executive Committee
2008-Present
Co-Organizer NSF Workshop on Organic Synthesis and Natural Products Chemistry
2007-2009
NIH Study Section (SBCB), Member 2006-Present
NIH Study Section, ad hoc, Med. Chem. 2005
NIH Special Study Section 2002, 2003 2004
Consultant: Rib-X Pharmaceuticals. 2002-2004
Associate Editor for the Americas: Tetrahedron Letters 2001-present
Consultant: Amgen 2006-present.
Consultant: Wyeth-Ayerst 2000-2004
Consultant: Eli Lilly: 2000-2001
American Cancer Society, External Grants Review Panel, ad hoc, 1997
NSF CAREER award referee 1997-2002, 2007
NIH Study Section, ad hoc, Med. Chem. A, 1999
American Cancer Society, External Grants Review Panel, member, 1999-2004
Beckman Foundation, Beckman Scholars Review Panel 1999.
Publications From Postdoctoral Work,
Harvard University
22. "Total Syntheses of Di- and Tri-O-Methyl Dynemicin A Methyl Esters" Jack Taunton, John L. Wood, and Stuart L. Schreiber J. Am. Chem. Soc. 1993, 115, 10378.
21. "Application of the Allylic Diazene Rearrangement: Synthesis of the Enediyne-Bridged Tricyclic Core of Dynemicin A" John L. Wood, John A. Porco, Jr., Jack Taunton, Angela Y. Lee, Jon Clardy, and Stuart L. Schreiber J. Am. Chem. Soc. 1992, 114, 5898.
Publications From Graduate Work,
University of Pennsylvania
20. "Pyrrolinone-Based Peptidomimetics" Ralph Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb, Terence Keenan, John L. Wood, Mark Guzman, Alexander Pasternak U.S. Patent 5,770,732.
19. "(+)-Trienomycins A, B, C, and F and (+)-Mycotrienins I and II: Relative and Absolute Stereochemistry" Amos B. Smith, III, John L. Wood, Weichyun Wong, Alexandra E. Gould, Carmelo J. Rizzo, Joseph Barbosa, Kanki Komiyama, Satoshi Omura J. Am. Chem. Soc. 1996, 118, 8308.
18. "Total Synthesis of (+)-Trienomycins A and F via a Unified Strategy" Amos B. Smith, III, Joseph Barbosa, Weichyun Wong, John L. Wood J. Am. Chem. Soc. 1996, 118, 8316.
17. "Pyrrolinone-Based Compounds" Ralph Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb, Terence Keenan, John L. Wood, Mark Guzman U.S. Patent 5,489,692.
16. "Total Synthesis of (+)-Trienomycins A and F" Amos B. Smith III, Joseph Barbosa, Weichyun Wong, and John L. Wood J. Am. Chem. Soc 1995, 117, 10777.
15. "Design and Synthesis of Nonpeptide Peptidomimetic Inhibitors of Renin" Amos B. Smith, III, Ryouichi Akaishi, David R. Jones, Terence P. Keenan, Mark C. Guzman, Ryan C. Holcomb, Paul A. Sprengler, John L. Wood, Ralph Hirschmann, M. Katherine Holloway Biopolymers (Peptide Science) 1995, 37, 29.
14. "General Photoisomerization Approach to trans-Benzobicyclo-[5.1.0.]octenes: Synthetic and Mechanistic Studies" Amos B. Smith, III, John L. Wood, Terence P. Keenan, Nigel Liverton, and Melean Visnick J. Org. Chem. 1994, 59, 6652.
13. "De Novo Design, Synthesis, and X-ray Crystal Structures of Pyrrolinone-Based β-Strand Peptidomimetics" Amos B. Smith, III, Mark C. Guzman, Paul A. Sprengeler, Terence P. Keenan, Ryan C. Holcomb, John L. Wood, Patrick J. Carroll, and Ralph Hirschmann J. Am. Chem. Soc. 1994, 116, 9947.
12. "The Design, Synthesis, and Crystal Structure of a Pyrrolinone-Based Peptidomimetic Possessing the Conformation of a β-Strand: Potential Application to the Design of Novel Inhibitors of Proteolytic Enzymes" Amos B. Smith, III, Terence P. Keenan, Ryan C. Holcomb, Paul A. Sprengeler, Mark C. Guzman, John L. Wood, Patrick J. Carroll, and Ralph Hirschmann J. Am. Chem. Soc. 1992, 114, 10673.
11. "Synthesis and Rearrangement Reactions of the First trans-Homotropone" Amos B. Smith, III and John L. Wood J. Am. Chem. Soc. 1992,114, 10075.
10. "Novel Structures of a trans-Cyclooctene and trans-Fused Cyclopropane Generated via Photoisomerization of a gem-Dichlorocyclopropyl Benzo--cycloheptenone" John L. Wood, Patrick J. Carroll, and Amos B. Smith, III J. Chem. Soc., Chem. Comm. 1992, 1433.
9. "Total Synthesis of the Cytotoxic Macrocycle (+)-Hitachimycin" Amos B. Smith, III, Thomas A. Rano, Noritaka Chida, Gary A. Sulikowski and John L. Wood, J. Am. Chem Soc. 1992, 114, 8008.
8. "(+)-Hitachimycin: Stereochemistry and Conformational Analysis" Amos B. Smith, III, John L. Wood, Carmelo J. Rizzo, George T. Furst, Patrick J. Carroll, Jerry Donohue, and Satoshi Omura J. Am. Chem. Soc. 1992, 114, 8003.
7. "Isolation and Structure Determination of (+)-Trienomycin F. An Endgame Synthetic Strategy for the Trienomycin Family of Antitumor Antibiotics" Amos B. Smith, III, John L. Wood, Alexandra E. Gould, Satoshi Omura, and Kanki Komiyama Tetrahedron Lett. 1991, 32, 1627.
6. "(+)-Mycotrienins I and II: Relative and Absolute Stereochemistry" Amos B. Smith, III and John L. Wood Tetrahedron Lett. 1991, 32, 841.
5. "A Versatile, Efficient Synthesis of (-)-(2S, 3R, 4S)-2-Amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane, The Abbott Pseudodipeptidyl Insert" John L. Wood, David R. Jones, Ralph Hirschmann, and Amos B. Smith, III Tetrahedron Lett. 1990, 31, 6329.
4. "Aphidicolin Synthetic Studies, 2. 2D-NMR Analysis of (+)-Aphidicolin and Its Degradation Products 3α,18-Dihydroxy-17-noraphidicolan-16-one and 3α,18-iso-propylidenedioxy-17-noraphidicolan-16-one. Complete 1H and 13C assignments" Carmelo J. Rizzo, John L. Wood, George T. Furst, and Amos B. Smith, III J. Nat. Prod. 1990, 53, 735.
3. "(+)-Trienomycins A, B, and C: Relative and Absolute Stereochemistry" Amos B. Smith, III, John L. Wood, Weichyun Wong, Alexandra E. Gould, Carmelo J. Rizzo, Shinji Funayama, and Satoshi Omura J. Am. Chem. Soc. 1990, 112, 7425.
2. "Solution and Crystal Structures of (+)-Hitachimycin (Stubomycin)" Amos B. Smith, III, John L. Wood, Carmelo J. Rizzo, George T. Furst, Patrick J. Carroll, Jerry Donohue, and Satoshi Omura J. Org. Chem. 1990, 55, 1133.
1. "An Efficient Photochemical Approach to the trans-Bicyclo[5.1.0]octene Ring System." John L. Wood, Nigel J. Liverton, Melean Visnick, and Amos B. Smith, III J. Am. Chem. Soc. 1989, 111, 4530.
