Therapeutic Materials and Biointerfacial Research Laboratory (TMBR)

Department of Chemistry and School of Biomedical Engineering

Colorado State University, Fort Collins, CO

Principal Investigator: Dr. Melissa M. Reynolds

CSU campus

Welcome

Interested graduate and undergraduate students are invited to contact Melissa Reynolds at melissa.reynolds@colostate.edu to discuss research opportunities for the current academic year.

ECC-NO ECC-control

Our research interests are in the study and development of advanced biocompatible materials. In most clinical applications, the introduction of a foreign material can lead to serious health risks and undesirable complications such as infection, blood clotting, and tissue growth. In our lab, we focus on synthesizing materials and artificial surfaces that replicate the natural function of endothelial cells through the release of nitric oxide (NO). These materials can effectively reduce or completely inhibit the complications associated with biologically-implanted materials. The current focus in our lab is on designing and developing biodegradable NO polymers, investigating the role of NO in cellular-material interactions, and engineering NO microdevices with the capability of controlling NO delivery dosages.

News and Updates

Recent Publications

Puiu, S. C.; Zhou, Z.; White, C.; Neubauer, L.; Lange, L. E.; Mansfield, J.; Meyerhoff, M. E.; Reynolds, M. M. Metal-Mediated Nitric Oxide Generation from Polyurethanes with Covalently Linked Cyclen/Cu(II) Moieties. Biomed. Materials Res. 2009, 91B(1), 203-212.

Xu, H.; Reynolds, M. M.; Cook, K. E.; Toscano, J. P. 2-Hydroxy-5-nitrobenzyl as a Diazeniumdiolate Protecting Group: Application in NO-Releasing Polymers with Enhanced Biocompatibility. Org. Lett. 2008, 10, 4593-4596.

Zhou, Z.; Reynolds, M. M.; Kampf, J. W.; Meyerhoff, M. E. 1,1'-Dimeth-oxy-3,3'-dimethyl-3,3'-(hexane-1,6-di-yl)bis(triazen-2-ium-2-olate): a nitric oxide donor. Acta Crystallogr C. 2009, 65(Pt 1), o1-o2.

Contact

E-mail

Melissa.Reynolds@colostate.edu

Mailing Address

Department of Chemistry
Colorado State University
Fort Collins, CO 80523

Telephone

Office: 970-491-3775
Fax: 970-491-1801