Therapeutic Materials and Biointerfacial Research Laboratory (TMBR)
Department of Chemistry and School of Biomedical Engineering
Colorado State University, Fort Collins, CO
Principal Investigator: Dr. Melissa M. Reynolds
Welcome
Our research interests are in the study and development of advanced biocompatible materials. In most clinical applications, the introduction of a foreign material can lead to serious health risks and undesirable complications such as infection, blood clotting, and tissue growth. In our lab, we focus on synthesizing materials and artificial surfaces that replicate the natural function of endothelial cells through the release of nitric oxide (NO). These materials can effectively reduce or completely inhibit the complications associated with biologically-implanted materials. The current focus in our lab is on designing and developing biodegradable NO polymers, investigating the role of NO in cellular-material interactions, and engineering NO microdevices with the capability of controlling NO delivery dosages.
News and Updates
- Dr. Reynolds has received an appointment as a member of the core faculty in the School of Biomedical Engineering.
- Graduate student Jackie Harding has joined the TMBR lab.
- Undergraduate students Nathan Zvejnieks and Stephen Gatlin have joined the TMBR lab.
- Congratulations to undergraduate researcher Jarrad McKay for his recognition as a Ram Scholar-Athlete.
- The TMBR lab would like to thank Paul West and Kodak corporation for their generous donation of lab equipment and supplies. We are especially grateful for the specialized polymer synthesis supplies.
- Lab renovations are now complete and the unpacking and ordering of new equipment and chemicals is underway.
- Dr. Reynolds has been invited to speak at Michigan Technological University College of Engineering; Spring 2010 (exact date TBA).
- Dr. Reynolds has been invited to speak at the MD&M West Conference; February 2010.
- Dr. Reynolds has been invited to speak at the CSU Animal Cancer Center; February 2010.
- Dr. Reynolds has been invited to speak at the 26th Annual Children's National Medical Center Symposium on ECMO and Advanced Therapies for Respiratory Failure, Keystone, CO; February 2010.
Recent Publications
Puiu, S. C.; Zhou, Z.; White, C.; Neubauer, L.; Lange, L. E.; Mansfield, J.; Meyerhoff, M. E.; Reynolds, M. M.
Metal-Mediated Nitric Oxide Generation from Polyurethanes with Covalently Linked Cyclen/Cu(II) Moieties.
Biomed. Materials Res. 2009, 91B(1), 203-212.
Xu, H.; Reynolds, M. M.; Cook, K. E.; Toscano, J. P.
2-Hydroxy-5-nitrobenzyl as a Diazeniumdiolate Protecting Group: Application in NO-Releasing Polymers with Enhanced Biocompatibility.
Org. Lett. 2008, 10, 4593-4596.
Zhou, Z.; Reynolds, M. M.; Kampf, J. W.; Meyerhoff, M. E.
1,1'-Dimeth-oxy-3,3'-dimethyl-3,3'-(hexane-1,6-di-yl)bis(triazen-2-ium-2-olate): a nitric oxide donor.
Acta Crystallogr C. 2009, 65(Pt 1), o1-o2.
Contact
Melissa.Reynolds@colostate.edu
Mailing Address
Department of Chemistry
Colorado State University
Fort Collins, CO 80523
Telephone
Office: 970-491-3775
Fax: 970-491-1801
