Melissa Reynolds

Melissa ReynoldsAssociate Professor of Chemistry and School of Biomedical Engineering
Office: Chemistry Research Building 115
Phone: 970-491-3775
Education: Ph.D., University of Michigan

Our research is multidisciplinary and focuses on the molecular design and fabrication of biomimetic materials for use in medical device applications. Depending on interests and expertise, group members are involved in a wide variety of research endeavors including:

  • synthesis of molecular, polymer, and extended framework biomaterials containing therapeutic functional groups
  • analytical and physical studies of biomaterials utilizing fluorescence, chemiluminesence, zeta potential, and LC/MS-TOF
  • fabrication and engineering of materials including spin-coating substrates and electrospinning nanofibers for tissue engineering
  • in vitro and in vivo efficacy and toxicity studies of biomaterials with potential translation to medical applications (preclinical studies done in collaboration with CSU Veterinary Medicine, UM Medical School, and Beaumont Research Hospital)
The group includes graduate and undergraduate students from the Department of Chemistry, Department of Chemical & Biological Engineering, Department of Biomedical Sciences, and the School of Biomedical Engineering.  Chemistry graduate students represent all divisions in the department including analytical, organic, inorganic, physical, and materials.

Selected Publications

Neufeld, M. J.; Lutzke, A.; Tapia, J. B.; Reynolds, M. M. Metal-Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S-Nitrosoglutathione in Aqueous Solution. ACS Appl. Mater. Interfaces. 2017, 9(6), 5139-5148. DOI: 10.1021/acsami.6b14937

Lutzke, A.; Tapia, J. B.; Neufeld, M. J.; Reynolds, M. M. Sustained Nitric Oxide Release from a Tertiary S-Nitrosothiol-based Polyphosphazene Coating. ACS Appl. Mater. Interfaces. 2017, 9(3), 2104-2113. DOI: 10.1021/acsami.6b12888

Neufeld, B. H.; Reynolds, M. M. Critical Nitric Oxide Concentration for Pseudomonas Aeruginosa Biofilm Reduction on Polyurethane Substrates. Biointerphases. 2016, 11, 031012. DOI: 10.1116/1.4962266 **Most read**

Neufeld, M. J.; Ware, B. R.; Lutzke, A.; Khetani, S. R.; Reynolds, M. M. Water-Stable Metal-Organic Framework/Polymer Composites Compatible with Human Hepatocytes. ACS Appl. Mater. Interfaces. 2016, 8, 19343–19352. DOI: 10.1021/acsami.6b05948

Neufeld, M. J.; Harding, J. H.; Reynolds, M. M. Immobilization of Metal-Organic Framework Copper(II) Benzene-1,3,5-Tricarboxylate (CuBTC) onto Cotton Fabric as a Nitric Oxide Release Catalyst. ACS Appl. Mater. Interfaces. 2015, 7, 26742–26750. DOI: 10.1021/acsami.5b08773

Yapor, J. P.; Lutzke, A.; Pegalajar-Jurado, A.; Neufeld, B. H.; Damodaran, V. B.; Reynolds, M. M. Biodegradable Citrate-Based Polyesters with S-Nitrosothiol Functional Groups for Nitric Oxide Release. J. Mater. Chem. B. 2015, 3, 9233-9241. DOI: 10.1039/C5TB01625H **Cover feature**

Pegalajar-Jurado, A.; Wold, K. A.; Joslin, J. M.; Neufeld, B. H.; Arabea, K. A.; Suazo, L. A.; McDaniel, S. L.; Bowen, R. A.; Reynolds, M. M. Nitric Oxide Releasing Polysaccharide Derivative Exhibits 8-log Reduction against Escherichia coli, Acinetobacter baumannii and Staphylococcus aureus. J. Controlled Release. 2015, 217, 228 – 234.(Invited). DOI: 10.1016/j.jconrel.2015.09.015

Harding, J. H.; Metz, J. M.; Reynolds, M. M. A Tunable, Stable and Bioactive MOF for Generating a Localized Therapeutic from Endogenous Sources. Adv. Func. Mater. 2014, 24, 7503-7509. DOI: 10.1002/adfm.201402529

Joslin, J. M.; Neufeld, B. H.; Reynolds, M. M. Correlating S-nitrosothiol Decomposition and NO Release for Modified Poly(lactic-co-gycolic acid) Polymer Films. RSC Adv. 2014, 4, 42039-42043. DOI: 10.1039/c4ra04817b

Harding, J. L; Reynolds, M. M. Accurate Nitric Oxide Measurements from Donors in Cell Media: Identification of Scavenging Agents. Anal. Chem. 2014, 86, 2025-2032. DOI: 10.1021/ac403174e

Sylman, J. L., Lantvit, S. M., Reynolds, M. M., Neeves, K. D. Transport Limitations of Nitric Oxide Inhibition of Platelet Aggregation Under Flow. Annals of Biomed. Engr. 2013, 41 (10), 2193-2205. DOI: 10.1007/s10439-013-0803-9

Lantvit, S. L., Barrett, B. J., Reynolds, M. M. Nitric Oxide Releasing Material Adsorbs More Fibrinogen. J. Biomed. Mater. Res. 2013, 101 (11), 3201-3210. DOI: 10.1002/jbm.a.34627

Reynolds, M. M., Witzeling, S. D., Damodaran, V. B, Medeiros, T. N., Edwards, M. A., Lookian, P. P.; Jarigese, D.; Brown, M. A. Application of a Nitric Oxide-Releasing Pro-Drug for Halting Growth of Human Breast and Canine Mammary Carcinoma Cells. J. Vet. Sci. & Med. 2012, 1, 1. DOI: 10.13188/2325-4645.1000002

Damodaran, V. B.; Place, L. W.; Kipper, M. J.; Reynolds, M. M. Enzymatically Degradable Nitric Oxide Releasing Dextran Derivatives for Biomedical Applications. J. Mater. Chem. 2012, 22 (43), 23038-23048. DOI: 10.1039/C2JM34834A

Wold, K. A.; Damodaran, V. B.; Suazo, L. A.; Bowen, R. A.; Reynolds, M. M. Fabrication of biodegradable polymeric nanofibers with covalently attached NO donors. ACS Appl. Mater. Interfaces. 2012, 4, 3022. DOI: 10.1021/am300383w

Damodaran, V. B.; Joslin, J. M.; Wold, K. A.; Lantvit, S. M.; Reynolds, M. M. S-Nitrosated biodegradable polymers for biomedical applications: synthesis, characterization and impact of thiol structure on the physicochemical properties.  J. Mater. Chem. 2012, 22, 5990-6001. DOI: 10.1039/C2JM16554F

Harding, J. L. and Reynolds, M. M. Metal Organic Frameworks as Nitric Oxide Catalysts. J. Am. Chem. Soc. 2012, 134, 3330. DOI: 10.1021/ja210771m

Joslin, J. M. and Reynolds, M. M. Kinetics of S-nitrosation Processes in Aqueous Polymer Solution for Controlled Nitric Oxide Loading: Towards Tunable Biomaterials. ACS Appl. Mater. Interfaces 2012, 4, 1126. DOI: 10.1021/am201807c

Damodaran, V. B.; Reynolds, M. M. Biodegradable S-Nitrosothiol Tethered Multiblock Polymer for Nitric Oxide Delivery. J. Mater. Chem. 2011, 21, 5870-5872. DOI: 10.1039/C1JM10315F

Reynolds, M. M. and Annich, G. A. The Non-Thrombogenic Endothelium. Organogenesis 2011, 7, 42-49. DOI: 10.4161/org.7.1.14029