In 1994 we discovered the first example of polyoxoanion and tetrabutylammonium stabilized Ir(0), Rh(0) and other transition-metal nanoclusters.  The polyoxoanion component of these nanoclusters, and their ability to undergo sustained catalytic reactions in solution—of more than 190,000 total catalytic cycles (total turnovers), are unprecedented.  Current efforts are focused on understanding their mechanism of formation, their high stability, and their catalytic reactions and mechanisms.  In addition, studies are in progress extending the classes of reactions catalyzed to important industrial reduction and oxidation reactions.  Some of this work is being done in collaboration with, and under support by, leading chemical companies from around the world.