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SUMMARY:Rapid, Single-Step Affinity Assays For Infectious Disease Detection
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20240320T160000
UID:2026-05-06-22-34-51@natsci.colostate.edu
DTSTAMP:20260506T223451
Description:About the Seminar:\n\nMedical diagnostics account for less than
  5% of total medical spending in the United States\, but the resulting tes
 ts influence more than 70% of the treatment decisions and subsequent care.
  Further\, the SARS-CoV-2 pandemic has underscored the need for rapid\, af
 fordable\, and user-friendly diagnostic tests. While traditional laborator
 y diagnostics such as PCR and ELISA are both sensitive and specific\, they
  require trained personnel\, an expensive laboratory setting\, and have a 
 long time-to-result\, making them generally costly and insufficient for fr
 equent screening. True at-home\, point-of-care diagnostic tests\, like lat
 eral flow assays (LFAs)\, are an attractive alternative due to their simpl
 icity and rapidity\; however\, many commercially available LFAs are often 
 criticized for their lower clinical sensitivity compared to traditional me
 thods. To improve upon point-of-care diagnostics\, we have developed a dev
 ice that utilizes a combination of microfluidics and enzyme/substrate inte
 ractions in order to improve sensitivity\, while retaining the rapid and u
 ser-friendly nature of LFAs. Our capillary-driven immunoassay (CaDI) facil
 itates the sequential delivery of reagents and washing steps\, akin to tho
 se traditionally found in laboratory well-plate enzyme-linked immunosorben
 t assays (ELISAs). With the use of these devices\, we successfully detecte
 d the SARS-CoV-2 nucleocapsid protein (Nprotein) in nasal swabs\, as well 
 as the Major Outer Membrane Protein (MOMP) of C. trachomatis (chlamydia) i
 n buffer. Our device is made of inexpensive material\, and requires a simp
 le\, single step\, with results that can be visually read in 15-20 minutes
 . 4:00 pm
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