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SUMMARY:Development of a Microfluidic Electrochemical Biosensor for Heart F
 ailure Biomarkers in Saliva
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20240410T160000
UID:2026-05-07-00-44-40@natsci.colostate.edu
DTSTAMP:20260507T004440
Description:About the Seminar: \n\nHeart failure (HF) is a leading cause o
 f death worldwide and continues to increase in prevalence as the general p
 opulation ages. Advances in the healthcare management of heart failure hav
 e led to lower morbidity and mortality rates but require accurate diagnost
 ics to guide the process. Current HF diagnostics require expensive equipme
 nt\, centralized facilities and trained personnel and invasive sampling\, 
 marginalizing healthcare in developing countries and rural communities. Ne
 w point-of-care (POC) diagnostic platforms that are portable\, affordable\
 , and use non-invasive samples can address this unmet need. Biosensors int
 egrated into microfluidic platforms for biological sample processing offer
  many advantages for POC applications because they are inexpensive\, porta
 ble\, and easy-to-use. However\, these platforms lack sensitivity\, the ab
 ility to provide quantitative results\, and the ability to process viscous
  biological samples. Electrochemical biosensors are sensitive\, quantitati
 ve analytical methods popular in POC diagnostics due to the potential for 
 inexpensive\, portable instrumentation. An emerging non-invasive biologica
 l sample matrix that does not require trained personnel to collect is sali
 va. Recently\, our team correlated concentrations of two salivary proteins
  (Galectin-3 and S100A7) to HF outcomes but no biosensors have been develo
 ped for measuring these biomarker levels at the POC. While saliva presents
  obstacles for processing in a microfluidic device\, the development of a 
 sensitive multiplexed POC biosensor for salivary biomarkers would improve 
 healthcare management of HF. This work demonstrates an electrochemical mul
 tiplexed sandwich immunoassay based on a screen-printed carbon electrodes 
 for the detecting the heart failure biomarkers\, galectin-3 and S100A7 in 
 pooled saliva samples. In parallel\, a novel capillary driven microfluidic
  platform that can process varying viscosities of saliva in less than 15 m
 inutes was developed. The proposed electrochemical immunoassay demonstrate
 d a linear signal response in the clinically relevant range and a limit of
  detection of 9.66 ng/mL (galectin-3) and 39.0 ng/mL (S100A7).  The preli
 minary results of the integration of the biosensor into the microfluidic p
 latform indicate the first step towards a robust and non-invasive electroc
 hemical sensor for HF biomarkers. 4:00 pm
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