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SUMMARY:Using Laser-Induced Graphene to Elevate the Performance of Electroc
 hemical Immunoassays
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20241009T160000
UID:2026-05-04-01-52-48@natsci.colostate.edu
DTSTAMP:20260504T015248
Description:About the Seminar: \n\nThe diagnosis of many human diseases is
  driven by the detection of one or more specific biomarkers. Rapid and sen
 sitive detection of these biomarkers is crucial in preventing further illn
 ess and/or the spread of the diseases within the individual and to other p
 eople. Microfluidic-based electrochemical immunoassays for biomarker detec
 tion have been explored as a practical alternative to time-consuming and e
 xpensive techniques such as polymerase chain reaction (PCR) and enzyme-lin
 ked immunosorbent assay (ELISA)\, which require highly trained personnel. 
 An important component in the fabrication of microfluidic devices is the e
 lectrode. Screen-printed carbon electrodes (SPCEs) are widely used due to 
 their potential for mass production\, and ease of printing directly onto t
 he microfluidic device. Relatively recently\, laser-induced graphene (LIG)
  has been explored for use as an electrode material in electrochemical bio
 sensors\, but there are limited examples of its use in microfluidic device
 s. Production of LIG electrodes is easy when compared to that of SPCEs\, r
 equiring only a CO2 laser cutter and a polymeric substrate\, like polyimid
 e\, capable of producing LIG. Fabrication of the electrodes occurs instant
 aneously through direct laser writing onto the substrate\, where high loca
 lized temperatures induce the conversion of the polymeric material into gr
 aphene. LIG electrodes also have excellent electrochemical properties that
  make them superior to traditional SPCEs. Their porous and highly graphiti
 c nature gives them high conductivity\, and electroactive surface areas mu
 ch larger than SPCEs. The automated production of LIG electrodes leads to 
 high reproducibility (&lt\;2% RSD) when they are characterized using elect
 rochemical techniques\, while the hands-on nature of the screen-printing p
 rocess introduces more error (up to 15%)\, decreasing performance. Future 
 work involves the development of a new process for implementing LIG electr
 odes into a microfluidic device for the subsequent execution of electroche
 mical immunoassays. 4:00 pm
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