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SUMMARY:Synthetic Control of Magnetic Resonance Properties Towards New Bioi
 maging Techniques
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220419T160000
UID:2026-04-24-06-01-41@natsci.colostate.edu
DTSTAMP:20260424T060141
Description:About the Seminar:\n\nElectron Paramagnetic Resonance Imaging (
 EPRI) stands to vastly improve the capabilities of non-invasive medical im
 aging techniques by harnessing the sensitivity of electronic spins. In ord
 er for this technique to reach viability\, a fundamental understanding of 
 how to design the necessary imaging agents is imperative. Much research ha
 s been conducted into EPRI imaging agents using organic radicals. However\
 , metal complexes may allow for EPRI to be conducted at high magnetic fiel
 ds with low-frequency microwave radiation. Additionally\, the synthetic tu
 nability afforded in metal complexes provides an abundance of ways to cont
 rol the electronic structure\, and thus the EPR spectra. Some key challeng
 es that need to be overcome before metal-based EPRI can be realized are br
 oad EPR spectral linewidths\, tailoring zero-field splitting in clathroche
 lates\, and an understanding how do design molecules for specific bioimagi
 ng purposes. A series of Cr(III) tris-diamine complexes were investigated 
 with L-band (1.36 GHz) EPR to understand how the ligand shell controls spe
 ctral linewidth. A series of Ni(II) clathrochelates were studied with magn
 etometry to determine the degree of zero-field splitting tunability at per
 ipheral locations. Two Mn(II) clathrochelates were examined with X-band EP
 R to understand how to design a viscosity sensitive EPR probe. The results
  of these studies will be discussed. 4:00 pm
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