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SUMMARY:Imaging and Controlling Molecular Compositions and Processes in Liv
 e Cells
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20230907T160000
UID:2026-05-17-19-41-32@natsci.colostate.edu
DTSTAMP:20260517T194132
Description:Abstract:\n\nA cell is a complex unity of various biomolecules 
 with diverse functions. Understanding molecular mechanisms in cells requir
 es detecting biomolecules with high chemical selectivity and resolution. C
 hemical imaging using optical modalities allows to visualize molecular com
 positions in cells with high spatial and temporal resolution. In this talk
 \, I will first review common linear and nonlinear chemical imaging techno
 logies such as fluorescence and coherent Raman scattering microscopy. A re
 cent development in improving the sensitivity of nonlinear optical microsc
 opy using a pulse-picking method will also be introduced. Next\, I will di
 scuss the recent development of a real-time precision opto-control (RPOC) 
 technology for precise control of molecular activities in live cells. This
  new technology enables new capabilities and understanding that cannot be 
 achieved in conventional ways. Applying RPOC\, we demonstrate selective co
 nversion of the state of photochromic molecules at desired locations of ce
 lls\, inducing reactive oxygen species at desired organelles\, inhibiting 
 tubulin polymerization at subcellular locations\, and quantifying the phot
 osensitization effect of common fluorescent dyes. RPOC also allows us to i
 nterrogate how femtosecond lasers with different average and peak power in
 teract with organelles and perturb cell functions.\n\n&nbsp\;\n\nAbout the
  Speaker: \n\nDr. Chi Zhang is an Assistant Professor at Purdue Universit
 y\, Department of Chemistry. He received his Ph.D. degree from the Univers
 ity of Michigan\, Department of Chemistry with a research emphasis in surf
 ace nonlinear optical spectroscopy supervised by Dr. Zhan Chen. He joined 
 Dr. Ji-Xin Cheng’s group at Purdue University in 2014 as a Postdoc Assoc
 iate working on chemical imaging and coherent Raman microscopy. He also di
 d his Postdoc work with Dr. Stephen Boppart at the University of Illinois 
 for biomedical imaging and spectroscopy before starting his independent re
 search career at Purdue University in 2020. The current research focus of 
 his lab is developing novel optical imaging and opto-control technologies 
 for biological applications. His lab pioneered the RPOC technology for pre
 cision optical manipulation of biomolecules in cells. He has published mor
 e than 50 peer-reviewed journal articles. His research is supported by the
  National Institute of Health\, the National Science Foundation\, and the 
 Center for Bioanalytical Metrology.\n\n&nbsp\; 4:00 pm
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