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SUMMARY:Does Orientation Matter? Designing a Library of Laccase Metalloenzy
 mes to Probe the Best Orientation for Catalysis
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20240216T160000
UID:2026-05-07-03-01-17@natsci.colostate.edu
DTSTAMP:20260507T030117
Description:About the Seminar: \nEnzymes have been integrated into electro
 des to form biosensors for nearly a century. To this date little work has 
 been done to study whether the orientation of the enzyme at the electrode 
 surface has a significant effect on the enzymes ability to catalyze a reac
 tion. For Direct Electron Transfer (DET) and catalysis to occur the electr
 ons and enzyme substrates must be mobile. Electrons must shuttle intra and
  intermolecularly with respect to the enzyme and in addition the substrate
 s must readily travel in and out of the active site(s). In order to probe 
 this\, a library of laccase enzymes mutated to be linked to a gold electro
 de with different orientation with respect to the planar electrode. Laccas
 es’ multiple active sites and substrate promiscuity makes it an ideal te
 st candidate to probe for nuance surrounding DET and any steric hinderance
  affecting complete catalysis within bioelectrodes and biosensors. 4:00 pm
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