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SUMMARY:New Broad Scope Catalytic Strategies for Amine and Complex Natural 
 Product Synthesis
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220204T160000
UID:2026-04-29-07-19-59@natsci.colostate.edu
DTSTAMP:20260429T071959
Description:About the Seminar:\n\nAmines are fundamental chemical motifs co
 mmonly found in molecules of importance to chemistry\, biology and medicin
 e. Their Lewis basic properties arising from the lone pair of electrons ma
 kes them ideal as ligands for transition metal catalysts and organometalli
 c complexes. In nature they are often found contained within alkaloid seco
 ndary metabolites produced by organisms such as bacteria\, fungi\, and pla
 nts. Many of these possess important pharmacological activities some of wh
 ich are exploited currently in the clinic. With such widespread utility an
 d application\, new strategic approaches for their synthesis allowing effe
 ctive\, reliable and broad-scope access would have far-reaching impact acr
 oss synthetic chemistry and into the biomedical sciences.\n\nIn this prese
 ntation\, new\, user-friendly broad scope reductive and oxidative strategi
 es using abundant nitrogen containing monomer sets – including amides\, 
 primary amines and imines – as substrates for carbon-carbon bond formati
 on will be described. The presentation will include details of the new syn
 thetic methodologies as well as their provenance and applications on compl
 ex natural product total synthesis. [1-5]\n\n\n\nReferences:\n\n 	\"Iridiu
 m-catalyzed reductive Ugi-type reactions of tertiary amides\" Xie\, L.\; D
 ixon\, D. J.  Sci. 2017\, 8\, 7492.\n 	\"Photocatalytic Three-Component Um
 polung Synthesis of 1\,3-Diamines\"\, T. Rossolini\, J. A. Leitch\, R. Gra
 inger\, D. J. Dixon\,  Lett. 2018\, 20\, 6794.\n 	\"Photocatalytic reverse
  polarity Povarov reaction\" A. Leitch\, A. L. Fuentes de Arriba\, J. Tan\
 , O. Hoff\, C. M. Martinez\, D. J. Dixon Chem. Sci. 2018\, 9\, 6653.\n 	
 \"Primary α-Tertiary Amine Synthesis via α-C–H Functionalization\"\, D
 . Vasu\, A. L. Fuentes de Arriba\, J. Leitch\, A. de Gombert and D. J. Dix
 on\,  Sci. 2019\, 10\, 3401.\n 	\"Iridium-Catalyzed Aza-Spirocyclisation o
 f Indole-Tethered Amides: an Interrupted Pictet-Spengler Reaction Gabriel\
 , A. Gregory\, D. J. Dixon\, Org. Lett. 2019\, 21\, 6658.\n 	\"General α-
 Amino 1\,3\,4-Oxadiazole Synthesis via Late-Stage Reductive Functionalizat
 ion of Tertiary Amides and Lactams\"\, D. Matheau-Raven and D. J. Dixon  C
 hem. Int. Ed. 2021\, DOI: 10.1002/anie.202107536\n 	\"General Pyrrolidine 
 Synthesis via Iridium-Catalyzed Reductive Azomethine Ylide Generation from
  Tertiary Amides &amp\; Lactams\"\, K. Yamazaki\, P. Gabriel\, G. Di Carmi
 ne\, J. Pedroni\, M. Farizyan\, T. A. Hamlin and D. J. Dixon ACS Catal. 20
 21\, 11\, 7489.\n\nAbout the Speaker:\n\nDarren J. Dixon is Professor of C
 hemistry at the University of Oxford. He obtained his BA\, MA and D. Phil 
 (supervised by Professor Stephen Davies) from the University of Oxford. Af
 ter a postdoctoral fellowship with Professor Steve Ley FRS he was appointe
 d to the Staff of the Department of Chemistry\, University of Cambridge in
  2000. In 2004 he took a Senior Lectureship at The University of Mancheste
 r and was promoted to Reader in 2007. In 2008\, he moved to his current po
 sition at Oxford where he is also the Knowles-Williams Tutorial Fellow in 
 Organic Chemistry at Wadham College. His research is centred on the develo
 pment of new catalyst-enabled synthetic methodologies and their applicatio
 n to the synthesis of structurally complex scaffolds\, natural products an
 d molecules of biological significance. His honors include an EPSRC Leader
 ship Fellowship\, the RSC Catalysis in Organic Chemistry Award\, the Astra
 Zeneca Research Award\, Novartis Lectureship\, Swiss Chemical Society Lect
 ureship.\n\nhttp://dixon.chem.ox.ac.uk/ 4:00 pm
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