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SUMMARY:A PChem Stroll Through the World of Single Molecule Microscopy: “
 Watching” Biology Happen, One Molecule at a Time
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20230420T160000
UID:2026-04-15-20-26-56@natsci.colostate.edu
DTSTAMP:20260415T202656
Description:About the Seminar\n\nThe ability to “see” single biomolecul
 es with laser microscopy has led to a revolution in research opportunities
  for chemistry\, physics and molecular biology. This talk will present a f
 ew short stories with the common theme of how we can use optical microscop
 y and single photon counting laser fluorescence methods to probe/measure t
 he folding of single nucleic acid molecules (e.g.\, DNA and RNA) in real t
 ime. I’ll first try to show how these single molecule methods can be use
 d to measure rates for conformational folding and unfolding\, as well as h
 ow we can influence folding of DNA and RNA by heating/cooling or addition 
 of ions (like Mg+2).  Time permitting\, I hope also to discuss the effect
  of molecular “crowding” relevant to how your DNA and RNA fold in vivo
  in your own cells\, as well as how we can extend these methods to extreme
  pressures (Pext = 4000 atmospheres!) up to 4x times higher than found in 
 the very deepest regions of the ocean floor! The unifying goal in this tal
 k will be the development of simple PChem pictures that help us interpret\
 , explain\, and potentially control/influence the biophysics of DNA and RN
 A folding at the single molecule level. 4:00 pm
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