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SUMMARY:Next-Generation Neurotechnology: Development Of Diamond-Based Neuro
 chemical Sensors And Characterization Of Electrode Integration With Brain 
 Tissue
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20250326T160000
UID:2026-04-26-18-57-06@natsci.colostate.edu
DTSTAMP:20260426T185706
Description:About the Seminar:\n\nBy stimulating or recording electrical or
  chemical signals generated by neurons\, microelectrode arrays implanted i
 n the brain have created a renaissance in the treatment and understanding 
 of neurological diseases and injuries. Likewise\, these devices are an ena
 bling technology to understand normal brain function and behavior. Ideally
 \, signal detection by chronic implants would be stable during the months 
 and years following implantation\, but fouling\, degradation\, and cellula
 r encapsulation of implants are all significant challenges to achieving st
 able\, long-term signal quality. Our lab’s primary goals are to: (1) imp
 rove the basic science understanding of the interaction between implanted 
 electrodes and brain cells\, and (2) to develop next-generation electrodes
  with improved chronic signal detection and stability. In the first part o
 f this talk\, I will describe our recent results illustrating the impacts 
 of implanted electrodes on the structure and function of local neurons\, i
 ncluding alterations in ion channel expression\, synaptic transporter expr
 ession\, dendritic spine density\, and excitability. These observations ar
 e complemented by molecular interrogation of tissue-device interactions us
 ing spatial transcriptomics and RNA-sequencing. In the second part of the
  talk\, I will describe our lab’s work to develop an all-diamond\, impla
 ntable ultramicroelectrode for neurochemical sensing via fast-scan cyclic 
 voltammetry (FSCV). Our results illustrate advantages of the diamond senso
 r for reduced biofouling and detection of neurotransmitters\, including se
 rotonin\, while introducing new questions and challenges.\n\nAbout the Spe
 aker: \nDr. Erin Purcell received her B.S. in Biomedical Engineering from
  Michigan Technological University (2001) and her M.S. and Ph.D. in Biomed
 ical Engineering from the University of Michigan (2004 and 2008). She comp
 leted a post-doctoral fellowship in the Kresge Hearing Research Institute 
 at the University of Michigan (2012). She subsequently joined Michigan Sta
 te University (MSU) as a senior research fellow in 2012 and was promoted t
 o the rank of Assistant Professor in the Fall of 2014 in the Department of
  Electrical and Computer Engineering. She became a founding faculty member
  of MSU’s new Department of Biomedical Engineering in 2016. She was tenu
 red as an Associate Professor in 2020. She became the Associate Chair for 
 the Department of Biomedical Engineering in 2022. At MSU\, Erin teaches 40
 0- and 800-level neural engineering and medical device innovation courses 
 to students from diverse backgrounds in engineering and life sciences. As 
 the P.I. of the Regenerative Electrode Interface Lab\, Dr. Purcell is purs
 uing new approaches to characterize\, modulate\, and regenerate neuronal r
 esponses at the interface of electrodes implanted in the brain. Her lab is
  funded by multiple NIH awards and an NSF CAREER award. 4:00 pm
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