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SUMMARY:Integrated Approaches for Quantitative Bioanalysis: Streamlined Pro
 teomics Analysis and Bio-Interface Engineering
LOCATION:Chemistry Research 401
TZID:America/Denver
DTSTART:20240822T120000
UID:2026-04-28-03-27-27@natsci.colostate.edu
DTSTAMP:20260428T032727
Description:About the Seminar:\n\nQuantitative analysis of biological syste
 ms and associated components is crucial in advancing our understanding of 
 modern biological sciences. In this talk\, I will share our effort in inte
 grating analytical chemistry\, bioengineering\, and material chemistry for
  constructing assays for quantitative bioanalysis. Specifically\, I would 
 first describe a Chip-DIA strategy for streamlined single-cell proteomic a
 nalysis. The assay is composed of a custom chip and data-independent acqui
 sition mass spectrometry (DIA-MS). Its analytical and proteomic profiling 
 performances\, as well its further extension to profile phosphoproteome fr
 om nanoscale samples (1-1000 cells) will be presented and discussed. Next\
 , I would share efforts in constructing bio-interfaces to probe and measur
 e integrin-mediated tension characteristics during neurite outgrowth in pr
 imary neurons\, which revealed a surface viscosity-dependent neuritogenesi
 s. These results shed light on complex biophysical mechanisms governing ce
 ll-interface interactions\, providing insights to develop advanced functio
 nal bio-interfaces.\n\n&nbsp\;\n\nPizza will be provided! 12:00 pm
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