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SUMMARY:Inaugural Anderson Lecture – Fluorescent Probes For Monitorin
 g The Dynamic Metalation State Of Metallo-Beta-Lactamases In Cells
LOCATION:Chemistry, A101
TZID:America/Denver
DTSTART:20231003T160000
UID:2026-05-04-23-00-28@natsci.colostate.edu
DTSTAMP:20260504T230028
Description:Abstract:\n\nNew Delhi Metallo-β-lactamase (NDM) grants resist
 ance to a broad spectrum of β-lactam antibiotics including last-resort ca
 rbapenems and is emerging as a global antibiotic resistance threat. Limite
 d zinc availability adversely impacts the ability of NDM-1 to provide resi
 stance\, but a number of clinical variants have emerged that are more resi
 stant to zinc scarcity. To provide novel tools to better study metal ion s
 equestration in host-pathogen interactions and the dynamic metalation stat
 e of NDM in these contexts\, we are developing fluorescent probes that bin
 d to the dizinc of active site of NDM. The development of reversible turn
 -on fluorescent probes for the metalation state of NDM provides a means to
  monitor the impact of metal ion sequestration by host defense mechanisms 
 and to detect inhibitor target engagement during the development of therap
 eutics to counter this resistance determinant. Recent developments in our 
 lab along this research theme will be discussed.\n\nAbout the Speaker: \n
 \nProf. Que received her B.S. in Chemistry from the University of Minnesot
 a. She continued on the pursue her Ph.D. in chemistry in Prof. Chris Chang
 \\'s lab at the University of California Berkeley\, where she developed me
 tal-responsive MRI contrast agents. She then moved to Northwestern Univers
 ity to work with Profs. Tom O\\'Halloran and Teresa Woodruff on understand
 ing the roles of zinc uring mammalian fertilization. She began her indepen
 dent career at the University of Texas at Austin in 2014 and was awarded t
 enure in 2021. Her research in the development of new bioinorganic imaging
  tools including metalloenzyme sensors and MRI contrast agents has been re
 cognized via the Saltman lectureship at the Metals in Biology Gordon resea
 rch conference\, an Emerging Investigator award from the Molecular Sensors
  and Molecular Logic Gates conference\, and NSF CAREER and NIH MIRA grants
 . 4:00 pm
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