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SUMMARY:Development of Alkene Difunctionalization Reactions Using Cationic 
 Nitrogen Salts
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20240513T160000
UID:2026-04-23-19-47-16@natsci.colostate.edu
DTSTAMP:20260423T194716
Description:About the Seminar: \n\nAlkenes are ubiquitous building blocks 
 in synthetic chemistry that are leveraged in difunctionalization strategie
 s to append multiple groups in one step. However\, methods to achieve this
  typically require specialized reagents\, directing groups\, and/or transi
 tion-metal catalysts for reactivity and reliable selectivity. Recent work 
 has shown 1\,3-alkene difunctionalization via charge relocation. Key to th
 is method is the use of acylium salts that form cyclic intermediates with 
 alkenes in a stepwise fashion that can be quenched with a nucleophile. Nit
 rilium salts represent an interesting analogue to acylium salts\, often en
 gaged as intermediates in a number of transformations such as the Schmidt\
 , Ugi\, and Ritter reactions. However\, nitrilium salts have not been repo
 rted in alkene difunctionalization reactions. Nitrilium ions would be idea
 l for alkene difunctionalization as they possess two modular R-groups and 
 the resulting imines can be further functionalized into ketone and amine p
 roducts. Additionally\, nitrilium ions are benchtop stable and easily acce
 ssible via nitrile alkylation/arylation or elimination from imidoyl chlori
 des. Similarly\, nitronium ions can serve as alternate reaction partners i
 n a nitration-functionalization process. Overall\, this proposal aims to d
 evelop effective 1\,2- and 1\,3- difunctionalizations of alkenes using nit
 rilium and nitronium salts. 4:00 pm
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