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SUMMARY:Teaching an Old Enzyme New Tricks: Synthesis of Stereodiverse P3HBs
  through Enzymatic Engineering of PHA Synthase
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20240513T160000
UID:2026-04-24-11-05-44@natsci.colostate.edu
DTSTAMP:20260424T110544
Description:About the Seminar: \n\nWith the ever-growing global plastics cr
 isis causing consistent damage to environmental and human health\, creatin
 g new and better biodegradable plastics is of the utmost importance. Poly(
 3-hydroxybutyrate) (P3HB)\, a biologically produced aliphatic polyester wi
 th an absolute stereoconfiguration of (R)\, is a great biodegradable candi
 date to replace commodity plastics having high strength and thermal proper
 ties with complete biodegradation in unmanaged conditions. One of the majo
 r reasons P3HB has not yet been widely commercialized is its extreme britt
 leness due to its perfectly isotactic stereomicrostructure. In this work m
 odifications to the enzyme used to create P3HB\, PHA synthase (PhaC)\, are
  proposed to create stereodiverse P3HBs\, which have been previously synth
 esized chemically and shown to be much less brittle materials due to intro
 duced stereoerrors. Overall\, this work aims to create mutants of PhaC tha
 t can incorporate both diastereomers of 3-hydroxybutyryl-CoA to create ste
 reodiverse P3HBs and subsequently compare these biologically derived P3HBs
  to current chemically derived P3HBs. 4:00 pm
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