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SUMMARY:Development Of A Robust Homologation Of Alcohols
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20250505T160000
UID:2026-04-30-08-03-00@natsci.colostate.edu
DTSTAMP:20260430T080300
Description:About the Seminar:\n\nOne-carbon homologation reactions constit
 ute a powerful set of chemical reactions\, due largely to the retrosynthet
 ic simplicity and utility afforded by introducing a methylene unit (–CH2
 –) adjacent to a functional group. These are fundamental reactions and c
 lassical versions\, such as the Arndt-Eistert reaction and Kowalski ester 
 homologation\, are frequently taught in undergraduate organic chemistry co
 urses. Classical one-carbon homologation reactions rely on harsh reagents 
 and are carried out over multiple steps\, and modern advancements seek to 
 simplify these transformations and make them more practical. Alcohols are 
 one of the most common functional groups in organic chemistry\, are pervas
 ive in bioactive molecules\, and can be transformed into a wide variety of
  other valuable functional groups. One-carbon homologation of alcohols has
  been achieved in a limited fashion\, but current methods proceed over mul
 tiple steps and function only on a narrow class of alcohols. I propose to 
 develop a practical and general one-pot homologation of alcohols – a tra
 nsformation that would inevitably find widespread adoption in organic synt
 hesis. 4:00 pm
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