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SUMMARY:Evaluation of the Adsorption-Accessible Surface Area of MIL-53(Al) 
 Using Cannabinoids in a Closed System
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220309T160000
UID:2026-04-29-05-17-35@natsci.colostate.edu
DTSTAMP:20260429T051735
Description:Cannabinoids are important industrial analytes commonly assayed
  with High Pressure Liquid Chromatography (HPLC). In this study\, we evalu
 ate the suitability of MIL-53(Al)\, a commercially available MOF as a stat
 ionary phase for cannabinoid separations. The suitability of a MOF for a g
 iven separation is hypothesized to be limited by the ability of a given mo
 lecule to enter the pore of the MOF.  To evaluate the extent of possible 
 adsorptive interactions between cannabinoids and the interior surface area
  of MIL-53(Al)\, the Radii of Gyration (Rg) and Solvent Accessible Surface
  Areas (SASAs) were calculated for three cannabinoids: cannabidiol (CBD)\,
  cannabinol (CBN)\, and Δ9-tetrahydrocannabinol (THC)\, as well as the MO
 F. These values were used to calculate the theoretical adsorption capacity
  of the MOF\, using four competing adsorption models. The Rg of cannabinoi
 ds (4.1 Å) is larger than one MOF pore aperture dimension (4.0 x 5.0 Å).
  The adsorption capacity was measured by relating a decrease in cannabinoi
 d concentration in acetonitrile when exposed to 100 mg MOF. Cannabinoid up
 take by the MOF was estimated using the relative standard deviation (RSD) 
 of the soaking solution assay\, as the Decomposition-Corrected RSD as Upta
 ke (DCRU). The DCRU was calculated as 0.007 ± 0.004 µgcannabinoids/mgMOF
 . These findings indicate that most of the MOF surface area was inaccessib
 le for adsorption by cannabinoids due to size-exclusion effects. The impli
 cation of this work is that the suitability of a MOF for adsorptive separa
 tions\, such as liquid chromatography\, must have an upper limit for size 
 of the analyte. Additionally\, MOFs may generally be more suitable for sep
 arations in the gas phase\, where adsorbates are not hindered by the prese
 nce of a solvation shell. 4:00 pm
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