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SUMMARY:Modifying Nitroarene Reactivity for New Electrophilic Aromatic Subs
 titution Reactions
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220531T160000
UID:2026-04-04-16-02-01@natsci.colostate.edu
DTSTAMP:20260404T160201
Description:About the Seminar:\n\nNitroarenes are an important class of mol
 ecules found in pharmaceuticals and used as synthetic intermediates in the
  synthesis of more complex molecules. Because nitroarenes are very pi-defi
 cient\, they are challenging to halogenate via electrophilic aromatic subs
 titution (EAS). Currently\, these molecules can be halogenated at the meta
  position using solvent quantities of strong acids and high temperatures\,
  which can be incompatible with many potential starting materials. Methods
  to halogenate the ortho and para positions are rare and these nitroarene 
 products are particularly in demand as they will further react with nucleo
 philes via nucleophilic aromatic substitution pathways. The purpose of thi
 s proposal is to develop strategies to facilitate electrophilic halogenati
 on of nitroarenes at all possible positions. The proposed reactions operat
 e via two distinct reaction platforms that effectively enhance the nucleop
 hilicity of nitroarenes. Specific Aim 1 describes a dearomatization strate
 gy\, while Specific Aims 2 and 3 describe a method that temporarily deriva
 tizes a nitro group to a 1\,3\,2-dioxazolidine ring. These methods would i
 mprove access to halogenated nitroarenes\, and the proposed reaction platf
 orms can potentially be expanded to electrophiles other than halogens\, en
 abling a diverse set of reactions. 4:00 pm
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