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SUMMARY:Rapid, Capillary-Driven Immunoassays for Improved Diagnostics
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220330T160000
UID:2026-04-27-21-11-14@natsci.colostate.edu
DTSTAMP:20260427T211114
Description:About the Seminar:\nMedical diagnostics account for less than 5
 % of total medical spending in the US\, but the results of those diagnosti
 cs influence more than 70% of treatment decisions and further care. Tradit
 ional laboratory diagnostics are costly in terms of both money and the tim
 e it takes to receive results. Most lab-based methods require expensive eq
 uipment\, trained personnel\, and a controlled laboratory setting\, making
  them inaccessible to many. Home tests\, like lateral flow assays (LFAs)\,
  are increasing in popularity due to their simplicity and user-friendlines
 s\, but often lack the clinical sensitivity required for certain types of 
 diagnostics. This has become more apparent over the last few years during 
 the SARS-CoV-2 pandemic. Many LFAs to diagnose either active infections or
  immunity to the virus have been approved for emergency use by the FDA\; h
 owever\, some have been cautioned against by the CDC because they lack sen
 sitivity or specificity. The devices that we have designed over the last t
 wo years use a combination of microfluidics and enzyme/substrate interacti
 ons to improve sensitivity of easy to use\, home diagnostics. The capillar
 y-driven immunoassay (CaDI) allows for sequential delivery of reagents and
  washing steps that would typically be performed in a laboratory-based enz
 yme linked immunosorbent assay (ELISA). Using these devices\, we have been
  able to detect SARS-CoV-2 IgG antibodies in whole human blood and SARS-Co
 V-2 nucleocapsid protein in nasal swab samples. The devices are designed f
 orm inexpensive materials\, require one or two end-user steps\, and result
 s can be read visually by the end-user in 15-20 min. 4:00 pm
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