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SUMMARY:Probing and Programming Biology via Protein Engineering
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20251027T160000
UID:2026-04-23-01-26-36@natsci.colostate.edu
DTSTAMP:20260423T012636
Description:About the seminar:\n\nCells continuously receive and interpret 
 signals from their surroundings and neighbors. These signals are necessary
  to guide essential processes such as metabolism\, migration\, and memory.
  In this talk\, I will discuss our work on engineering new proteins that e
 nable cells to detect external cues based on mechanical forces\, enzyme ac
 tivity\, and bio-orthogonal chemical reactions. First\, I will describe th
 e molecular strategies used to design and validate these proteins and then
  highlight how these systems can transduce extracellular information into 
 intracellular changes in transcription and translation. In addition\, I wi
 ll introduce new tools we have developed to visualize and control mRNAs at
  the single-molecule level. Overall\, this talk will emphasize how chemica
 l toolmaking and molecular insights can deepen our understanding of cellul
 ar processes and offer new strategies to probe and program mammalian cell 
 function. Together\, these efforts demonstrate how chemical toolmaking and
  molecular engineering can advance our understanding of cellular signaling
  and provide new strategies to probe and reprogram mammalian cell function
 .\n\nAbout the speaker:\n\nJohn Ngo is an Associate Professor of Biomedica
 l Engineering at Boston University. He earned his Ph.D. in Biochemistry an
 d Molecular Biophysics from Caltech and completed postdoctoral research at
  UC San Diego (2012–2015). His lab develops chemical and biophysical too
 ls to probe\, manipulate\, and reprogram the processes governing how biolo
 gical macromolecules are produced and organized within cells. These tools 
 are used to reveal new insights into cellular biology and to address chall
 enges in engineering therapeutic cells\, RNAs\, and proteins. 4:00 pm
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