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SUMMARY:Exploring photoredox-catalyzed reactions to make synthetic cannabin
 oids for neurodegenerative applications
LOCATION:Virtual Seminar - Zoom
TZID:America/Denver
DTSTART:20220502T160000
UID:2026-05-16-03-56-37@natsci.colostate.edu
DTSTAMP:20260516T035637
Description:About the Seminar:\n\nThis work will explore photoredox-Ni dual
  catalyzed sp2-sp3 cross-coupling\, Diels-Alder\, and hetero Diels-Alder r
 eactions towards their use in synthesizing synthetic cannabinoids. These t
 ransformations are critical for medicinal chemistry applications to enable
  reactions between electron-rich dienes and electron-rich dienophiles and 
 difficult sp3-sp2 cross-coupling reactions.  Additionally\, these reactio
 ns can be used to synthesize JWH133 and nabilone\, synthetic cannabinoids 
 and potential candidates to treat Alzheimer’s.1 An increased interest in
  cannabinoids for various medicinal applications creates a need for robust
  synthetic methods. Traditionally\, cannabinoids have been synthesized usi
 ng hetero Diels-Alder reactions which often involve elevated temperatures 
 and pressures.2\,3 These methods are often not feasible which creates a ne
 ed for alternative synthetic routes. Photoredox-catalyzed reactions will p
 rovide easier access to reactive radical intermediates\, resulting in more
  high-yielding syntheses and easier derivatization of compounds.4-7 The ob
 jective of this proposal is to obtain fundamental knowledge about using ph
 otoredox-catalyzed sp2-sp3 cross-coupling\, Diels-Alder and hetero Diels-A
 lder reactions to synthesize biologically relevant molecules. For example\
 , JWH133 and nabilone (Figure 1)\, which are synthetic cannabinoids of hig
 h interest that have been studied for the treatment of Alzheimer’s disea
 se\, will be used as a proof of concept to utilize proposed transformation
 s.1 The proposal will determine 1) the substrate scope of photoredox-Ni du
 al catalyzed sp2-sp3 cross-coupling and Diels-Alder reactions and 2) the c
 hoice of the catalyst for photoredox-catalyzed hetero Diels-Alder reaction
 s. Ultimately\, this knowledge will be used to provide easily accessible t
 ransformations to make other synthetic cannabinoids that are difficult to 
 access via traditional synthetic transformations.\n\nZoom Link to Attend S
 eminar: \n\nJoin Zoom Meeting\n\nhttps://zoom.us/j/93711313540?pwd=UFA1Mm
 JHVlZmL0FzZVdoMlA2eWdUQT09\n\nMeeting ID: 937 1131 3540\n\nPasscode: 1872 
 4:00 pm
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