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SUMMARY:Living on Nitrogen
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20251007T160000
UID:2026-03-15-23-09-18@natsci.colostate.edu
DTSTAMP:20260315T230918
Description:About the seminar:\n\nSome of the most abundant microorganisms 
 on Earth do not live as we do––rather than using carbon-based fuels\
 , they instead rely on the oxidation of ammonia to furnish reducing equiva
 lents for life. These ammonia oxidizing bacteria and archaea (AOB and AOA)
  pervade every ecosystem\, where they drive key reactions of the nitrogen
  cycle collectively referred to as “nitrification.” Constantly increa
 sing use of nitrogen-based fertilizers by humans has been a boon to AOB a
 nd AOA\, which excrete waste products that pollute drinking water and lead
  to ecological imbalances such as algae blooms. Despite the global impact 
 of nitrification\, its underlying biochemistry and structural biology rema
 ins ripe for inquiry. This lecture will describe studies by the Lancaster 
 Group to elucidate metallocofactor-catalyzed transformations underpinning 
 the primary metabolisms used by AOB and AOA to oxidize ammonia and subsequ
 ent intermediates towards generation of their common stoichiometric produc
 t\, nitrite. Key topics will include the identification of nitric oxide as
  an obligate intermediate of bacterial nitrification\, control of selectiv
 ity in hydroxylamine oxidation\, and mechanisms of generation of nitrous o
 xide as a common waste product by both AOA and AOB.\n\n&nbsp\;\n\nAbout th
 e Speaker:\n\nKyle Lancaster\, a native of Orange County\, CA\, received h
 is B.A. in Molecular Biology from Pomona College in 2005. He next earned a
  Ph.D. in Chemistry at Caltech in 2010 after studying artificial biologica
 l copper electron transfer proteins with Harry Gray. He completed a brief 
 postdoc at Cornell University with Serena DeBeer during which he helped to
  develop X-ray emission spectroscopy as a tool to study metalloproteins. H
 e has since remained at Cornell\, where he runs an interdisciplinary resea
 rch program merging synthesis\, biochemistry\, structural biology\, and sp
 ectroscopy. Current research foci are understudied pathways in the biogeoc
 hemical nitrogen cycle and atom transfer reactivity carried out by base 
 metals. 4:00 pm
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