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SUMMARY:From Small Molecules to Biologics: Exploring Polarity Reversal Stra
 tegies for Novel Therapeutic Opportunities
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20231009T160000
UID:2026-05-18-13-58-40@natsci.colostate.edu
DTSTAMP:20260518T135840
Description:Abstract:\n\nThe synthesis of small molecules and biologics usi
 ng polarity reversal (umpolung) strategies has the potential to transform 
 drug discovery by tapping into previously underexplored reagents and mecha
 nisms. In this lecture\, I will present our research on the use of umpolun
 g methods to build and functionalize small molecules\, carbohydrates\, pep
 tides\, and proteins. Specifically\, I will discuss the reactions of anome
 ric nucleophiles\, their stereoretentive transformations\, and our recent 
 studies with AlaM reagents\, which have led to broadly applicable methods 
 in preparative carbohydrate/peptide chemistry. Our translational studies h
 ave also shown the potential of these strategies to generate new anti-infe
 ctive leads\, underscoring their significance in advancing drug discovery.
  In broader terms\, our work highlights the importance of polarity reversa
 l strategies as a vehicle for chemical innovations and the potential for t
 hese strategies to enable the development of novel therapeutics.\n\n&nbsp\
 ;\n\nAbout the Speaker:\n\nMaciej Walczak received his undergraduate degre
 e (maxima cum laude) from Adam Mickiewicz University in Poznan\, Poland. I
 n 2003 he started his graduate studies at the University of Pittsburgh\, w
 here he worked on the synthesis and reactions of strained carbocycles. Aft
 er graduating in 2009\, he moved to New York as a Brodeur Foundation postd
 octoral fellow at Memorial Sloan-Kettering Cancer Center\, where he was in
 volved in the synthesis of glycoproteins\, anticancer vaccines\, and antim
 etastatic agents. In August 2013 he started his independent career at the 
 University of Colorado Boulder as an Assistant Professor of Chemistry and 
 was promoted to Associate Professor in 2020. 4:00 pm
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