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SUMMARY:Dissecting the Bioinorganic Chemistry of the Extracellular Space
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20230425T160000
UID:2026-04-22-05-11-27@natsci.colostate.edu
DTSTAMP:20260422T051127
Description:About the Seminar\n\nThe context in which a metal resides withi
 n a biological environment significantly influences its activity in functi
 on. Recent years have seen a rise in tools for monitoring metal ions and h
 ave illuminated the diversity in metal speciation in biology\, but many of
  these tools are focused on probing metals in the intracellular space. The
  state-of-the-art methods for assessing metal status in extracellular flui
 ds such as blood plasma focus either on absolute quantitation or evaluate 
 a limited number of metal- containing species. While these methods have of
 fered important insight into extreme cases of metal deficiency in overload
 \, subtle imbalances are more challenging to diagnose and understand. This
  talk will describe our efforts to expand and elucidate metal speciation a
 nd its dynamics in the extracellular space\, specifically in the blood pla
 sma and the interstitial space. We will discuss molecular-level investigat
 ions of extracellular biomolecules and their interactions with metal ions\
 , the development of tools to selectively probe extracellular metal biolog
 y\, and the impacts our research can have in discovering biomarkers that l
 ink metal micronutrient homeostasis\, diet\, and metabolic disorders.\n\nA
 bout the Speaker \n\nMarie Heffern is an assistant professor of chemistry
  at the University of California\, Davis\, where she started in August 201
 7. She obtained a dual degree in Chemistry (B.S.) and Religion (B.A.) from
  the University of Southern California where she researched low-temperatur
 e synthetic routes to perovskite nanocrystals with Richard L. Brutchey. Sh
 e earned her Ph.D. at Northwestern University with Thomas J. Meade investi
 gating metal complexes as protein inhibitors. Following her graduate studi
 es\, she trained with Christopher Chang at the University of California\, 
 Berkeley\, researching in vivo imaging probes for redox-active metals. Her
  research group focuses on interdisciplinary approaches within the field o
 f bioinorganic chemistry with a particular emphasis in metals in medicine.
  Specifically\, the team is investigating the impact and applications of m
 etals in diet and disease\, with a focus on endocrine disorders. 4:00 pm
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