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SUMMARY:Characterization of Bottlebrush Polymer Protein Coronas through Mic
 roMapping
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20230503T160000
UID:2026-04-27-08-10-54@natsci.colostate.edu
DTSTAMP:20260427T081054
Description:Research Seminar -\n\nAbstract: Bottlebrush polymer prodrugs ar
 e an important emerging class of synthetic macromolecules for biomedical a
 pplications such as gene and drug delivery. Currently\, there exists a lac
 k in understanding of how bottlebrush polymer prodrugs interact with prote
 ins in biological media. It is known that when foreign particles (such as 
 synthetic macromolecules) of a particular size are introduced into blood s
 erum proteins rapidly accumulate onto their surfaces forming a “protein 
 corona.” Importantly\, the formation of protein coronas around foreign p
 articles ultimately changes their intended biological identity and effects
  biodistribution\, pharmacokinetics\, cell uptake\, etc. As such\, it is i
 mportant to understand how to control protein corona formation especially 
 for synthetic macromolecules designed for gene and drug delivery. Standard
  approaches for protein corona characterization are not viable for small (
 ~10 nm) macromolecules such as bottlebrush polymer prodrugs nor are they s
 uited for elucidating the dynamics of protein corona formation over short 
 durations of time. This lack of technology and gap in understanding poses 
 a critical barrier in advancing the efficacy of bottlebrush polymer prodru
 gs. In the proposed work\, an emerging technology (MicroMapping) in photoc
 atalyzed proximity labeling will be leveraged to realize the first example
  of time-resolved and in situ characterization of molecular bottlebrush po
 lymer protein coronas. Overall\, this work will introduce a new tool for c
 haracterizing the protein coronas of small nanoparticles\, provide the fir
 st protein corona map of molecular bottlebrush polymers\, and significantl
 y augment the clinical translation of bottlebrush polymer prodrugs. 4:00 p
 m
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