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SUMMARY:Single Atom Logic for Skeletal Editing
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20230918T160000
UID:2026-04-24-02-30-50@natsci.colostate.edu
DTSTAMP:20260424T023050
Description:Abstract:\n\nReactions which can manipulate the connectivity of
  the molecular skeleton are underexplored as tools for late-stage function
 alization\, in part because their implementation has been hindered by thei
 r often nonintuitive retrosynthetic logic. This presentation will cover se
 lected transformations discovered in our laboratory which address this cha
 llenge by enabling single-atom changes to aliphatic and aromatic systems t
 hrough the insertion and deletion of single heavy atoms (C\,N\,O\, etc.)\,
  as well as more complex manipulations leveraging combinations of these el
 ementary transformations. Our approach to this problem is modality-agnosti
 c\, drawing from a wide range of reactive species and synthetic discipline
 s\, but with a significant focus on reagent design and photochemistry. App
 lications to late-stage functionalization and diversification of complex p
 harmaceutically relevant compounds as well as unique opportunities for syn
 thesis will be presented alongside mechanistic findings.\n\n&nbsp\;\n\nAbo
 ut the Speaker:\n\n\n\n\n\nMark was born and raised in Cleveland\, OH as t
 he oldest of three children in a Russian-Jewish immigrant family. In 2012\
 , he earned a B.S. in chemistry from the University of Rochester in Roches
 ter\, NY\, conducting undergraduate research with Professor Alison J. Fron
 tier on an oxidative variant of the Nazarov cyclization. Through participa
 tion in the DAAD RISE program\, Mark also spent the summer of 2010 conduct
 ing research with Henning Hopf at TU Braunschweig on the synthesis of stra
 ined hydrocarbons. After graduation\, he joined the laboratory of Professo
 r F. Dean Toste at the University of California\, Berkeley. There\, he stu
 died the chemistry of the Au(I)/Au(III) redox couple in several contexts\,
  including supramolecular catalysis and fluorine-18 radiosynthesis. After 
 earning his Ph.D. in 2017\, Mark joined the laboratory of Professor Eric N
 . Jacobsen as an NIH Postdoctoral Fellow at Harvard University where his r
 esearch focused on enantioselective fluorination reactions with chiral org
 anoiodane catalysts. In 2019\, Mark joined the University of Chicago as an
  assistant professor of chemistry and was promoted to associate professor 
 with tenure in 2022. His research interests include the development of syn
 thetic methodology and study of their mechanisms\, with a specific focus o
 n “single-atom skeletal editing”.\n\n\n\n\n\n\n\n 4:00 pm
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