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SUMMARY:Gatekeeping the Iron: How the Polypeptide Regulates Catalysis in An
 imal Lipoxygenases
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20260312T160000
UID:2026-04-15-19-59-07@natsci.colostate.edu
DTSTAMP:20260415T195907
Description:Seminar Abstract:\nUnderstanding proteins in their native envir
 onments and the full conformational landscapes they explore is essential f
 or linking structure to function. This seminar focuses on lipoxygenases (L
 OXs)\, a family of non-heme\, primarily iron-containing enzymes that catal
 yze the regio- and stereospecific oxygenation of polyunsaturated fatty aci
 ds (PUFAs) released from membranes by phospholipases. While phospholipases
  rely on membrane interfaces for activation\, certain LOXs exhibit a remar
 kable duality: they remain active in soluble systems but demonstrate accel
 erated catalysis at lipid-water interfaces. This presentation will delve i
 nto the molecular basis of this \"interfacial acceleration\" across the LO
 X phylogeny\, a critical knowledge gap in the field. By integrating evolut
 ionary biochemistry\, AI-driven structural predictions\, advanced biophysi
 cal techniques\, and crystal/cryo-EM structures\, this work uncovers conse
 rved mechanisms of LOX activation. Ultimately\, the findings provide new i
 nsights into motion-based drug design targeting key human lipoxygenases.\n
 \nSpeaker Bio:\n\nIt is my pleasure to introduce Dr. Nathan Gilbert. He e
 arned both his B.S. and Ph.D. at LSU\, completing his doctoral research in
  Dr. Marcia Newcomer’s laboratory in 2011. Following his time at LSU\, N
 athan moved to Vanderbilt Medical Center\, where\, as a postdoctoral fello
 w in the laboratories of Dr. Tina Iverson and Dr. Rich Breyer\, he explore
 d G protein-coupled receptors involved in eicosanoid signaling\, with a pa
 rticular focus on prostaglandin E2 receptors. Nathan\\'s career path next 
 led him into biotechnology\, where he worked with a start-up company devel
 oping novel biophysical techniques for detecting protein-small molecule in
 teractions. After recognizing the uncertainty facing the company\, Nathan 
 returned to Baton Rouge\, accepting a position as Beamline Manager at the 
 LSU Center for Advanced Microstructures and Devices (CAMD). His expertise 
 and leadership soon earned him a promotion to research assistant professor
 \, where he secured his own R15 grant to support his independent research.
  In August 2024\, Nathan returned back to the campus of LSU in a new role 
 as a tenure-track assistant professor in the Department of Biological Scie
 nces\, within the Biochemistry and Molecular Biology division. Nathan will
  now share his research interests and the techniques he utilizes to probe 
 macromolecular interactions.\n\n 4:00 pm
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