BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//ZContent.net//ZapCalLib 1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
SUMMARY:Near-Infrared Chemiluminescent Nanoparticles for In Vivo Optical Im
 aging
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20220425T160000
UID:2026-03-15-23-59-14@natsci.colostate.edu
DTSTAMP:20260315T235914
Description:About the Seminar:\n\nImaging techniques are a vital part of cl
 inical diagnostics and biomedical research. Optical molecular imaging make
 s use of relatively harmless\, low-energy light\, and technically straight
 forward instrumentation. Bioluminescence imaging systems\, particularly us
 e of firefly luciferin\, are attractive because they have inherently high 
 signal contrast due to the lack of background emission. However\, current 
 bioluminescence imaging involves short-lived molecular species that are no
 t stored and they typically emit visible light which does not penetrate fa
 r through heterogeneous biological media. Here\, we describe a new paradig
 m for optical molecular imaging using singlet oxygen encapsulated inside a
  nanoparticle with near-infrared fluorescent dye molecules. Chemiluminesce
 nce can be stored indefinitely at temperatures below -20 oC\, but upon war
 ming to body temperature it undergoes a chemical reaction and emits near-i
 nfrared light that can pass through a living mouse. The whole-body image o
 f chemiluminescence in our recent works provides a capability to image dee
 p-tissue sites (&gt\; 4 cm) and consequently our optical imaging protocols
  can be utilized for the early diagnosis and identification of tumor sites
  such as head and neck cancer and pancreatic cancer.\n\n\n\nAbout the Spea
 ker:\n\nDr. Jung-Jae Lee is the principal investigator of the Laboratory o
 f Nanomedicine at Colorado University Denver (CU Denver)\, Anschutz Medica
 l Campus (AMC). He received his PhD degree in the Department of Chemistry 
 and Biochemistry from the University of Notre Dame in 2009. After his post
 doctoral trainings at Notre Dame Integrated Imaging Facility (NDIIF)\, MIT
 \, and Harvard Medical School\, he took an Assistant Professor position in
  the Department of Chemistry at CU Denver in 2015. His research focuses on
  nanomedicine for clinical use in a wide range of topics in drug delivery\
 , biomaterials\, and molecular imaging. He is an affiliated faculty member
  of Bioengineering and a core member of Colorado Clinical and Translationa
 l Sciences Institute (CCTSI) and University of Colorado Cancer Center (UCC
 C) at AMC. 4:00 pm
END:VEVENT
END:VCALENDAR