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SUMMARY:How Do Cell Penetrating Peptides Cross the Membrane?
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20250324T160000
UID:2026-05-03-19-41-28@natsci.colostate.edu
DTSTAMP:20260503T194128
Description:About the Seminar:\n\nWe aim at elucidating the molecular mecha
 nism of passive membrane crossing of cell penetrating peptides\, such as o
 ligoarginines\, using a combination of fluorescence and cryoelectron micro
 scopies and molecular dynamics simulations.  Recently\, we have shown usi
 ng atomistic simulations that calcium dications can induce membrane fusion
  in vesicles rich in phosphatidylethanolamine. Moreover\, we have shown th
 at arginine-rich peptides are similarly fusogenic and have suggested that 
 from mechanistic point of view the passive membrane penetration of arginin
 e-rich peptides may be analogous to calcium-induced membrane fusion. Here\
 , we employ fluorescence and cryo-electron microscopies on vesicles and ce
 lls combined with simulations to elucidate the molecular details of passiv
 e cell entrance of arginine-rich peptides. The experimental results point 
 to a hitherto unexplored mechanism involving induction of membrane multila
 mellarity\, potentially followed by a process analogous to calcium-induced
  membrane fusion.\n\n\n\n&nbsp\;\n\nAbout the Speaker:\n\nPavel Jungwirth 
 is a Distinguished Chair at the Institute of Organic Chemistry and Biochem
 istry\, Czech Academy of Sciences (group head since 2004). Since 2000\, he
  has been a professor (external faculty) at the Charles University in Prag
 ue\, Faculty of Mathematics and Physics. He has more than 280 research and
  review papers in international journals with more than 11000 citations (H
 -index 56). Several book chapters. Numerous invited lectures at internatio
 nal conferences (including GRC) and research laboratories in Europe\, Isra
 el\, and USA. You can learn more about Dr. Jungwirth and his research here
 : http://jungwirth.uochb.cas.cz/cv.php 4:00 pm
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