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SUMMARY:Vibrational Investigation of Lipid Bilayer Interiors at Specific De
 pths
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20251113T160000
UID:2026-05-18-07-59-35@natsci.colostate.edu
DTSTAMP:20260518T075935
Description:About the seminar:\n\nLipid bilayers form the basis of the cell
  membrane\, with the hydrophobic bilayer interior acting as the solvent fo
 r membrane proteins. These bilayers undergo a temperature-induced phase tr
 ansition from an ordered phase to a disordered phase which affects membran
 e protein structure and functionality. Depth-dependent spectroscopic studi
 es can describe these phase transitions. However\, common methods either u
 se large probes which can disrupt the bilayer or cannot access fast enough
  time scales to describe ultrafast molecular processes. Vibrational spectr
 oscopy can overcome both of these limitations. The paper I will discuss (I
 slam et al.\, J. Am. Chem. Soc. 2023\, 145\, 48\, 26363–26373) introduc
 es a set of test compounds composed of an azide group bonded to an alkyl c
 hain of varying lengths. The azide vibrational probe sits at specific dept
 hs within a model bilayer system depending on the alkyl chain length. This
  probe allows for FTIR and ultrafast 2D-IR investigations of the lipid bil
 ayer at different depths without disturbing the bilayer interior. The meth
 od described in this paper could be used to describe the effects of a phas
 e transition at specific locations on membrane proteins\, elucidating biol
 ogical consequences of phase transitions. 4:00 pm
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