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SUMMARY:Molecular Dynamics in Nanoconfinement via Single-Molecule Fluoresce
 nce Correlation Spectroscopy
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20251016T160000
UID:2026-05-05-23-05-17@natsci.colostate.edu
DTSTAMP:20260505T230517
Description:About the seminar:\n\nChemistry under nanoconfinement exhibits 
 fundamentally different behavior compared to bulk systems\, such as altere
 d thermodynamic properties and molecular dynamics. Understanding these con
 fined environments is critical for applications ranging from drug delivery
  and water purification to catalysis. While we can observe the initial and
  final states in these processes\, the dynamic behavior of individual mole
 cules within nanoconfined spaces remains poorly understood. This presentat
 ion discusses recent work utilizing anodic aluminum oxide (AAO) membranes 
 as a practical model system to investigate confinement effects on molecula
 r transport. Employing fluorescence correlation spectroscopy (FCS)\, the d
 iffusion of rhodamine B (RhB) was observed through individual AAO pores\, 
 enabling direct observation of single molecule dynamics in one-dimensional
  nanoconfinement. The measurements reveal bimodal diffusion behavior that 
 was absent in bulk solution: a fast diffusion component that\, while exhib
 iting behaviors similar to that of bulk RhB diffusion\, exhibits reduced m
 obility attributable to electrostatic interactions between the charged dye
  and AAO pore walls accompanied by hydrodynamic drag from an immobile wate
 r layer adsorbed at the pore-solution interface\, and a slow diffusion com
 ponent arising from reversible adsorption-desorption events at the pore su
 rface. These findings demonstrate how nanoconfinement alters transport mec
 hanisms available to molecular species\, highlighting the relationship bet
 ween geometric constraints\, interfacial interactions\, and molecular dyna
 mics in nanoscale environments. 4:00 pm
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