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SUMMARY:Chemistry that Impacts Medicinal Chemistry
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20241014T160000
UID:2026-04-18-23-39-07@natsci.colostate.edu
DTSTAMP:20260418T233907
Description:About the Seminar: \n\nPyridines and diazines are ubiquitous in
  pharmaceuticals and agrochemicals\, yet there are limits in synthetic met
 hods that can directly functionalize the C–H bonds in these structures. 
 We will show two distinct approaches\, using phosphorus and ring-opened in
 termediates\, that enable selective functionalization of these heterocycle
 s into a range of valuable derivatives. A range of C–C and C–Heteroato
 m bond formations are viable\, and the chemistry functions on structures t
 ypically encountered in drug discovery programs. Our lab has also performe
 d mechanistic and computational studies of the regioselectivity of these r
 eactions and the phosphorus ligand-coupling processes involved. 4:00 pm
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