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SUMMARY:Multifunctional Electrochemical Probes using Aptamers for Chemical 
 Sensing and Imaging
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20260128T160000
UID:2026-04-29-10-36-29@natsci.colostate.edu
DTSTAMP:20260429T103629
Description:Abstract:\n\nSingle-stranded nucleic acid aptamers\, also known
  as synthetic antibodies\, are widely used in sensing owing to their high 
 selectivity and the range of detectable target analytes. A major challenge
 \, however\, is the fabrication of aptamer-based sensors with sufficiently
  small dimensions to enable localized\, spatially resolved measurements in
  complex biological environments. In this talk\, our efforts to integrate 
 aptamer-based sensing probes with scanning electrochemical techniques to i
 nvestigate chemical heterogeneity at the single-cell level will be present
 ed. With a focus on probe design and fabrication\, we are using self-assem
 bled monolayers of thiolated aptamers on gold nanostructures confined with
 in nanopipettes and on microscale electrode surfaces. These complementary 
 platforms allow real-time monitoring of target analyte concentrations and 
 can be coupled with imaging modalities. By incorporating aptamers into the
  imaging probes of scanning electrochemical microscopy (SECM) and scanning
  ion conductance microscopy (SICM)\, we demonstrate new routes to high-spa
 tial-resolution specific detection\, including for non-redox-active specie
 s.\n\nSpeaker Bio:\n\nRobert Lazenby is an Assistant Professor in the Depa
 rtment of Chemistry and Biochemistry at Florida State University. He recei
 ved his PhD in Chemistry from the University of Warwick\, where he worked 
 under the supervision of Patrick Unwin and Julie Macpherson\, and complete
 d postdoctoral training with Ryan White at the University of Maryland Balt
 imore County and the University of Cincinnati. His research focuses on ele
 ctrochemistry and bioanalytical chemistry\, including the development of s
 canning electrochemical probe microscopies\, aptamer-based electrochemical
  and ion conductance sensors\, and multifunctional biosensor probes for si
 multaneous analyte detection. His group’s work\, recently supported by a
 n NIH MIRA award\, aims to provide new insights into cellular processes an
 d disease-relevant chemistry. 4:00 pm
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