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SUMMARY:Maximizing the Potential of Dioxygen in Synthetic Aerobic Oxidation
  Reactions
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20240325T160000
UID:2026-05-21-04-04-59@natsci.colostate.edu
DTSTAMP:20260521T040459
Description:About the Seminar:\n\nLiquid phase aerobic oxidations in chemis
 try and biology feature a variety of different mechanisms for O2 activatio
 n and use as an oxidant. Radical-chain mechanisms involve the formation or
 ganic radicals that react directly with O2. Monooxygenase enzymes feature 
 reductive activation of O2 to generate a reactive two-electron oxidant\, s
 uch as a metal-oxo species\, that promotes oxygen-atom transfer to an orga
 nic molecule. Many homogeneous and heterogeneous catalysts for aerobic oxi
 dation promote mechanisms similar to oxidase enzymes that couple two redox
  half-reactions consisting of (i) the two- or four-electron oxygen reducti
 on reaction (ORR) and (ii) oxidation of an organic substrate. This oxidase
 -type mechanism resembles redox reactions in electrochemistry and fuel cel
 ls\, drawing attention to the issue of ORR “overpotential” in syntheti
 c reactions ((Stamoulis et al. J. Am. Chem. Soc. 2023\, 145\, 17515-17526)
 . In fuel cells\, the ORR overpotential (hORR) influences the accessible c
 ell potential (Ecell\, Figure A). In aerobic oxidations\, the thermodynami
 c efficiency of the ORR step (hORR)\, directly impacting the thermodynamic
  driving force available for oxidation of the substrate (hsub). Manifestat
 ions of these concepts differ for homogeneous and heterogeneous catalysts.
  This talk will discuss the implications of the dioxygen activation mechan
 ism and ORR overpotential in liquid-phase aerobic oxidation reactions\, in
 cluding both homogeneous and heterogeneous catalysts. Homogeneous catalyst
 s often exhibit high hORR that limits the scope of accessible reactivity.\
 n\nMore information about the speaker and his research group can be found 
 here.\n\n&nbsp\; 4:00 pm
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