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SUMMARY:The Total Synthesis of Cassane Diterpene Tomocin A
LOCATION:Virtual Research Proposal Presentation
TZID:America/Denver
DTSTART:20209100T000000
UID:2026-04-22-19-05-11@natsci.colostate.edu
DTSTAMP:20260422T190511
Description:Pancreatic cancer is the fourth leading cause of cancer deaths 
 in men and women. In general\, pancreatic tumors are hypovascular and nutr
 ient-deprived when compared to normal tissue or other cancer lines. As suc
 h\, new cancer therapeutics are being investigated that utilize the “ant
 i-austerity” strategy. An anti-austerity agents removes the ability of c
 ancer cells to survive under nutrient deficient condition while cells with
  adequate nutrition remain unaffected. Isolated from kernels of Vietnamese
  Caesalpinia sappan Linn (Caesalpiniaceae)\, tomocin A and other related d
 iterpenes have been found to display anti-austerity abilities towards PANC
 -1 cancer lines. The goal of the current work would be to propose the firs
 t total synthesis of tomocin A. The route would go through intermediates t
 hat could be exploited to synthesize related cassane diterpenes that also 
 exhibit anti-austerity properties. The first total synthesis of phanginin 
 K will also be accomplished in the route towards tomocin A. Through the to
 tal synthesis of tomocin A\, and access to related derivatives\, a structu
 re activity relationship (SAR) analysis of the diterpenes against pancreat
 ic cancer could be examined.\n\n&nbsp\; 9:00 am
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