BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//ZContent.net//ZapCalLib 1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
SUMMARY:Nitric Oxide Generation from S-Nitrosothiols by Metal–Organic Fra
 mework Composites for Thromboresistant Medical Device Materials
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20211110T160000
UID:2026-04-28-19-35-14@natsci.colostate.edu
DTSTAMP:20260428T193514
Description:Research Seminar:\n\nA systematic approach for evaluating both 
 the chemical and physical properties of materials for medical devices is n
 ecessary to achieve optimal performance. Metal–organic frameworks (MOFs)
  are highly-ordered\, crystalline coordination polymers consisting of meta
 l centers connected by organic linkers\, useful for a variety of applicati
 ons from gas storage to catalysis. To facilitate their incorporation into 
 medical devices\, MOFs can be developed into composite materials. Herein\,
  the MOF H3[(Cu4Cl)3(BTTri)8] (H3BTTri = 1\,3\,5-tris(1H-1\,2\,3-triazol-5
 -yl)benzene)\, or CuBTTri\, was incorporated into a composite with a hydro
 philic polyurethane. This MOF is of particular interest for use in biomedi
 cal applications because of its demonstrated stability under physiological
  conditions and ability to catalyze the release of nitric oxide (NO) from 
 endogenous S-nitrosothiols. Due to its antiplatelet and antiproliferative 
 properties in the vascular system\, NO has been shown to reduce medical de
 vice-induced thrombosis when generated at the surface of blood-contacting 
 devices. We take a systematic approach to quantify the effects MOF loading
 \, MOF preparation\, and polymer thickness on the catalytic properties of 
 CuBTTri. With this data we can tune the components of the composites to fa
 bricate better thromboresistant composite materials for blood-contacting m
 edical devices such as extracorporeal membrane oxygenation devices and imp
 lantable glucose sensors. 4:00 pm
END:VEVENT
END:VCALENDAR