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SUMMARY:Boulder Scientific Distinguished Lecture – Organocatalytic Po
 lymerization: Generation of New Gene Delivery Agents
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20189001T000000
UID:2026-05-16-04-20-32@natsci.colostate.edu
DTSTAMP:20260516T042032
Description:We have developed a family of selective organic catalysts for r
 ing-opening polymerization reactions.1\,2  In parallel efforts\, we have 
 developed new oxidation catalysts2 that generate new monomers which were t
 hen enchained using organocatalytic polymerization1 to generate functional
  materials that proved useful agents for the delivery of messenger RNA int
 o living animals.4-6 Functional delivery of messenger RNA (mRNA) in-vivo i
 s key to implementing potentially transformative strategies for vaccinatio
 n\, protein replacement therapy and genome editing. The step-economical sy
 nthesis and evaluation of a new\, tunable and effective class of synthetic
  biodegradable materials: charge-altering releasable transporters (CART
 s) will be described for mRNA delivery. CARTs are structurally unique and 
 operate through an unprecedented mechanism\, serving initially as oligo(α
 -amino ester) cations that complex\, protect and deliver mRNA\, and then c
 hange physical properties through a degradative\, charge-neutralizing intr
 amolecular rearrangement\, leading to intracellular release of functional 
 mRNA and highly efficient protein expression. 4:00 pm
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