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SUMMARY:Development of Fluorescent Probes for the Detection of Ethylene
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20195001T000000
UID:2026-04-26-03-46-21@natsci.colostate.edu
DTSTAMP:20260426T034621
Description:About the Seminar\n\nEthylene is an important plant hormone tha
 t is involved in a variety of developmental processes including agricultur
 ally important ripening of certain fruits. Owing to its significant roles\
 , a number of approaches have previously been developed to detect ethylene
  via molecular interactions. However\, there are no current approaches for
  detection that are selective via a discrete homogeneous molecular interac
 tion. Our group has developed profluorescent chemodosimeters for the selec
 tive detection of the plant hormone ethylene. The approach consists of a B
 ODIPY fluorophore with a pendant ruthenium recognition element based on a 
 Hoveyda-Grubbs 2nd generation catalysts. A marked increase in fluorescence
  is observed upon exposure to ethylene and selectivity is observed for eth
 ylene over other alkenes\, providing a unique approach towards ethylene de
 tection. We can image ethylene in live cells from multiple relevant source
 s.\n\nAbout the Speaker\n\nBrian Michel received his B.S. in Chemistry fro
 m Western Washington University in 2006. Brian was then drawn to the snow 
 and research at the University of Utah\, where he completed his Ph.D. with
  Prof. Matthew Sigman. In the Sigman Lab\, Brian developed a highly select
 ive variant of the Wacker oxidation. During this time he gained an appreci
 ation for using mechanistic insight to develop and optimize reactions. In 
 2011\, Brian moved west to work with Prof. Chris Chang at the University o
 f California\, Berkeley\, where he designed small molecule fluorescent pro
 bes for the detection of carbon monoxide in live cells and developed a pas
 sion for detecting biologically relevant analytes based on biocompatible r
 eactivity. Brian joined the faculty at the University of Denver Fall 2014.
  His group is interested in using the reactivity of transition metals to d
 evelop new synthetic methods and design probes for the detection of biolog
 ically relevant small molecules. 4:00 pm
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