BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//ZContent.net//ZapCalLib 1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
SUMMARY:Imaging biological ions in vivo using responsive MRI agents
LOCATION:A101
TZID:America/Denver
DTSTART:20180201T000000
UID:2026-04-24-21-51-29@natsci.colostate.edu
DTSTAMP:20260424T215129
Description:About the Seminar:\n\nMagnetic resonance imaging (MRI) is often
  considered too insensitive for molecular imaging of biological processes.
  Although many Gd3+-based contrast agents have been reported in the chemis
 try literature over the past 30 years\, only a few have been demonstrated 
 to provide important biological information in vivo. A key parameter in th
 e design of more sensitive Gd3+-based MRI contrast agents is the rate of w
 ater exchange. Our approach to optimize this rate will be illustrated in t
 he design of sensors for in vivo imaging of free Zn2+ ions released from t
 he pancreas and prostate in response to glucose. Insulin produced by pancr
 eatic -cells is stored in granules as a zinc complex which is released 
 in response to high glucose. As a result\, the local concentration of Zn2+
  ions in the extracellular space of -cells during insulin secretion inc
 reases to ~400 M and as we have demonstrated\, this change is readily d
 etected by MRI using a zinc-responsive agent. The normal human prostate ha
 s been reported to have the highest levels of free Zn2+ while malignant pr
 ostate cells undergo a metabolic transformation that results in less accum
 ulation of Zn2+. This loss of tissue Zn2+ in prostate cancer offers a pote
 ntial opportunity to distinguish malignancy from benign prostatic hyperpla
 sia (BPH)\, and inflammation. The ability to fine-tune water exchange rate
 s is also key in maximizing the sensitivity of paramagnetic chemical excha
 nge saturation transfer (paraCEST) agents. The chemistry of these novel re
 porters and their limitations for use in vivo to image tissue pH and tissu
 e redox will be discussed. Other MR techniques\, including CEST imaging an
 d hyperpolarized nuclei also offer considerable potential for providing ne
 w insights into the tumor microenvironment and tumor metabolism.\n\n&nbsp\
 ;\n\nAbout the Speaker:\n\nA. Dean Sherry is currently a Professor of Chem
 istry at the University of Texas at Dallas. He is the Director of the Adva
 nced Imaging Research Center\, at UT-Southwestern.   He is also a Profess
 or of Radiology at the University of Texas Southern Medical Center in Dall
 as.  As well as a Distinguished Chair in Systems Biology\, at UT-Dallas. 
   Dr. Sherry is also the associate editor of Contrast Media &amp\; Molecu
 lar Imaging\, for John Wiley.  Among his many awards\, in 2015 he won the
  Gold Medal Award for the International Society for Magnetic Resonance in 
 Medicine (ISMRM).  He currently has 455 publications. 4:00 pm
END:VEVENT
END:VCALENDAR