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SUMMARY:A synthetic base-triple motif for nucleic acid structure-function a
 nd delivery
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20188201T000000
UID:2026-04-25-20-21-01@natsci.colostate.edu
DTSTAMP:20260425T202101
Description:We and others have demonstrated the use of triaminotriazine (me
 lamine) as a synthetic base-triple motif in a family of molecules we call 
 bifacial peptide nucleic acid (bPNA). Bifacial PNA engages two oligo T/U s
 trands simultaneously to form a unique triple stranded structure. bPNAs ca
 n serve as allosteric triggers of aptamer protein-binding\, ribozyme catal
 ysis\, aptamer small-molecule binding and scaffolds for potent siRNA deliv
 ery. Peptoid\, polyacrylate and small molecules have all been demonstrated
  to be functional bPNAs. Small molecules displaying melamine can target T/
 U bulges in folded nucleic acid structures and trigger cooperative folding
  in unstructured oligo T/U domains. This targeting strategy has been appli
 ed to develop fluorogen sensing G-quadruplex based RNA aptamers and NMR-pr
 obes for RNA-binding protein domains. Overall\, a wide range of applicatio
 ns emerge from the use of a simple artificial base triple unit. 4:00 pm
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