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SUMMARY:Flow-Based Electrochemical Paper-Based Devices for Point-of-Care Te
 sting
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20193001T000000
UID:2026-05-05-18-16-42@natsci.colostate.edu
DTSTAMP:20260505T181642
Description:Research Seminar Abstract:\n\nPaper has been used as a platform
  in analytical measurement since the early 1800s but has recently received
  significant recent attention as a substrate for microfluidic devices.1 Mi
 crofluidic paper-based analytical devices (μPADs) are low-cost\, can faci
 litate reagent storage within the fiber network\, and can provide fluid tr
 ansport through capillary action without external pumps. Various μPADs ha
 ve been reported to date for point-of-care (POC) applications featuring co
 lorimetric and/or electrochemical detection.2 Electrochemical detection fo
 r μPADs (ePADs) is an attractive alternative to colorimetric methods due 
 to its high sensitivity and tunable selectivity through choice of the elec
 trode material\, electrochemical technique and potential. The first part o
 f my talk will focus on development of a quasi-steady flow on ePAD to enab
 le semi-automation in sample processing similar to conventional flow injec
 tion analysis. As a proof of concept\, an enzyme kinetics study was conduc
 ted with the ePAD using β-galactosidase and p-aminophenyl-galactopyranosi
 de as enzyme and substrate\, respectively. Using the proposed ePAD\, simil
 ar kinetic value (Km\, Michaelis-Menten constant) to those reported in lit
 erature was successfully obtained.3 The second part of the talk will focus
  on the incorporation of thermoplastic electrode (TPE) arrays to the flow 
 ePAD to improve sensitivity of the detection. The electrodes were fabricat
 ed using graphite and cyclic olefin copolymer using a simple solvent assis
 ted method. Low limit of detection (64 nM ferrocene complex) as well as ga
 in in sensitivity were achieved using this TPE-ePAD.4\n\n(1) Martinez\, A.
  W.\; Phillips\, S. T.\; Butte\, M. J.\; Whitesides\, G. M. Angew. Chemie 
 - Int. Ed. 2007\, 46 (8)\, 1318–1320.\n(2) Yang\, Y.\; Noviana\, E.\; Ng
 uyen\, M. P.\; Geiss\, B. J.\; Dandy\, D. S.\; Henry\, C. S. Anal. Chem. 2
 017\, 89 (1)\, 71–91.\n(3) Adkins\, J. A.\; Noviana\, E.\; Henry\, C. S.
  Anal. Chem. 2016\, 88 (21)\, 10639–10647.\n(4) Noviana\, E.\; Klunder\,
  K. J.\; Channon\, R. B.\; Henry\, C. S. Anal. Chem. 2019\, 91\, 2431–24
 38. 4:00 pm
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