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SUMMARY:Understanding Ribosome Specific Antibiotic Resistance Through MINFL
 UX
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20181001T000000
UID:2026-05-17-20-20-54@natsci.colostate.edu
DTSTAMP:20260517T202054
Description:Literature Seminar Abstract\n\nAntibiotic resistance is a criti
 cal problem facing society.1 Ribosomal targeting is a well-established pat
 hway for developing antibiotics and understanding how physiological riboso
 mes change conformation as antibiotics bind is crucial to developing new a
 ntibiotics.1 Though ribosomal conformation has been studies in vitro\, few
  in vivo studies have been accomplished.1 Recently\, Balzarotti et al deve
 loped a new super-resolution fluorescence imaging technique they call MINF
 LUX due to the minimal photon counts needed to generated nanometer resolve
 d images.2\,3 Built on the principles of STED and PALM/STORM\, MINFLUX loc
 alizes photon emitters by probing local intensity minima and can be used t
 o image and track fluorescently labelled macromolecules in living cells.2\
 ,3 Though it has yet to be used to study conformational changes of ribosom
 es\, MINFLUX presents an opportunity to investigate in vivo ribosomal conf
 ormational changes and track ribosomes as they diffuse through living cell
 s\, providing information that can be used to develop better antibiotics i
 n the face of antibiotic resistance.\n\nCitations:\n\n [1] Wilson\, D.N.\
 , Ribosome-targeting antibiotics and mechanism of bacterial resistance\, N
 at. Rev. Microbiol.\,  12\, 35–48 (2014) [2] Balzarotti\, F.\, Eilers\,
  Y.\, Gwosch\, K.C.\, Gynna\, A.H.\, Westphal\, V.\, Stefani\, F.D.\, Elf\
 , J.\, Hell\, S.W.\, Nanometer resolution imagind and tracking of fluoresc
 ent molecules with minimal photon fluxes\, Science\, 355 606-612 (2017) [3
 ] Eilers\, Y.\, Haisen\, T.\, Gwosch\, K.C.\, Balzarotti\, F.\, Hell\, S.W
 .\, MINFLUX monitors rapid molecular jumps with superior spatiotemporal re
 solution\, PNAS\, 115\, 6117-6122 (2018) 4:00 pm
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