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SUMMARY:Utilizing Nitroreductases for the Biocatalytic Reduction of Nitro G
 roups to Make Amines
LOCATION:Chemistry A101
TZID:America/Denver
DTSTART:20190101T000000
UID:2026-04-29-06-03-06@natsci.colostate.edu
DTSTAMP:20260429T060306
Description:About the Seminar:\n\nAmine functional groups are both ubiquito
 us and important throughout many industries. Amines are a common motif in 
 pharmaceuticals\, as amino acid building blocks\, mimicking amine-based ne
 urotransmitters\, or to improve solubility of drug formulations. One of th
 e most common ways to add amines to molecules is via nitration and subsequ
 ent reduction. However\, there are limited methods to reduce nitro groups 
 to amines in the presence of other functional groups with environmentally 
 friendly conditions. Biocatalysis\, harnessing enzymes to perform non-natu
 ral reactions\, is of growing interest to organic chemists to perform gree
 n\, efficient transformations with high selectivity and yield. In this pro
 posal\, a broad range of aliphatic and aromatic amines will be synthesized
  biocatalytically using nitroreductase enzymes. Nitroreductases are a fami
 ly of enzymes found in bacteria known be able to reduce nitro groups to am
 ines. Reaction conditions will be optimized to produce amines from a broad
  range of nitro-containing substrates. Protein modeling will be used to de
 termine useful mutations or eliminate mutations with negative effects. Fin
 ally\, semi-rational directed evolution will be performed\, and the mutate
 d enzymes will be screened to find hits with increased yield. Ultimately\,
  the goal of this proposal is to develop a library of nitroreductase enzym
 es that reduce aliphatic and aromatic nitro groups to amines in high yield
 . 4:00 pm
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