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SUMMARY:Linking Polyoxometalates to Antibodies for Use of Cancer Treatment
LOCATION:Virtual Seminar
TZID:America/Denver
DTSTART:20210607T163000
UID:2026-04-26-14-57-10@natsci.colostate.edu
DTSTAMP:20260426T145710
Description:Independent Research Proposal\n\nAbstract\n\nThis proposal cont
 ains a synthesis to make a class of anti-cancer compounds for a potential 
 immunotherapy treatment. We propose a new form of antibody drug conjugate 
 that uses polyoxometalates (POMs) as a drug payload to increase the effica
 cy of oncolytic viruses for cancer treatment. Oxovanadates have a synergis
 tic effect with oncolytic viruses\; they increase replication by inhibitin
 g the immune system that would normally target the virus. However\, vanada
 tes react with bio metabolites under physiological conditions\, limiting i
 ts potential use. To achieve maximum effect of the vanadates without side 
 reactions we will use a cluster of vanadate with an antibody transport sys
 tem that will transport the polyoxometalate to the cancer site before they
  fall apart. To achieve this\, we will combine peptide chemistry technique
 s and polyoxometalate chemistry to design linkers that can bind to both th
 e antibody and the polyoxometalate\, functionalize the POM to be able to b
 ind to linkers\, and bind the anionic metal linker complex to the antibody
 . We are proposing to synthesize an antibody drug conjugate that contains 
 a polyoxometalate\, a linker\, and a chosen antibody. The drug payload wil
 l be the polyoxometalate in the form of decavanadate or another lacunary p
 olyoxometalate\, the linker will be a peptide or a polyethylene glycol typ
 e linker and the antibody we have chosen is Bevacizumab.\n\n&nbsp\;\n\nZoo
 m Link\n\nPasscode 1872 4:30 pm
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